Senior Scientist I - Oncology Research

PrincetonOne; San Francisco (CA); On-site; USD 120,000 - 190,000; Full time

Job summary

PrincetonOne is seeking a Senior Scientist I to join its Oncology Research team. The successful candidate will lead early discovery programs and hands‑on develop complex cell‑based assays to characterize novel biologics, with opportunities to progress programs through IND‑enabling studies.

The role requires design and execution of high‑quality experiments, thorough data analysis, and clear documentation, with collaboration across departments to drive decisions and advance oncology research goals.

Qualifications

• PhD required in a relevant life sciences field.
• 4–6 years of industry experience (may include industry post‑doc).
• Experience with cell culture, cytotoxicity assays, flow cytometry, and cytokine analysis is required.
• Leadership of early discovery programs and ability to work independently.

Responsibilities

• Lead research programs and collaborate with line functions to define strategic direction and execute programs.
• Design, implement, analyze, and report high‑quality experiments to enable decision making.
• Maintain thorough records of procedures and results.
• Present data at project team meetings and internal reviews with key stakeholders.

Skills

Cell culture

Cytotoxicity assays

Flow cytometry

Cytokine analysis

ADC characterization

Independent thinking

Communication skills

Education

PhD in Cell Biology, Cancer Biology, Immunology, or related field

Job description

Our client is a clinical-stage biotechnology company committed to changing the treatment of cancer through a novel, proprietary therapeutic platform. Their commitment to transforming lives with safer, more effective therapies is driven by curiosity, a passion for innovation, and a belief that acting with integrity in an honest, respectful, ethical manner gives them the power to change lives. Their workplace embodies collaboration, open communication, celebrating successes, and holding each other to the highest possible standards. The company's robust and differentiated pipeline spans multiple treatment modalities, including antibody-drug conjugates (ADCs), T-cell engagers, and immune modulators such as cytokines, with several programs advancing through clinical development.

Who You Are and What You'll Do

We are seeking a highly motivated and experienced Senior Scientist I to join the Oncology Research team. The successful candidate will have hands‑on experience leading early discovery research programs and teams, and will be technically skilled in developing and executing complex cell‑based assays to characterize novel biologics. The candidate will have the opportunity to lead programs from discovery through the progression of IND‑enabling studies, working collaboratively across departments. In this role, the individual will design and conduct high‑quality experiments independently. They will be responsible for data analysis, thorough documentation of work, and clear communication of results.

Job Responsibilities

• Lead research programs and work collaboratively with line functions to define strategic direction and execute on programs
• Design, implement, analyze, and report high‑quality experiments to enable decision making
• Keep detailed, accurate, and up‑to‑date records of all experimental procedures and results
• Present data at project team meetings and internal reviews with key stakeholders

Minimum Qualifications

• PhD in Cell Biology, Cancer Biology, Immunology, or related field
• 4-6 years of industry experience (may include industry post‑doc)
• Proven expertise with laboratory techniques including cell culture, cytotoxicity assays, flow cytometry, and cytokine analysis is required
• Hands‑on experience with functional characterization of ADCs through lead selection
• Demonstrated track record of independent critical thinking and scientific achievement in oncology
• Ability to work independently and to thrive in a highly collaborative, fast‑paced, team‑oriented environment with colleagues from diverse disciplines is essential
• Outstanding oral and written communication skills, critical thinking and problem‑solving skills are required
• Please note that presentation of a scientific seminar is required during the interview process

Preferred Qualifications

• Strong background in immunology, and experience working with immunotherapy is preferred
• Excellent leadership and influencing skills

How You Will Work

• Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
• Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
• Exhibits strong interpersonal skills and self‑awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
• Shows continuous improvement and a commitment to self‑management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
• Demonstrates a patient focus. Puts the patient first in actions and decisions taken.