Senior Research Associate, Analytical Development - Separation Sciences

Scorpion Therapeutics; Lexington (MA); On-site; USD 90,000 - 140,000; Full time

Job summary

Takeda is seeking a Senior Research Associate in Analytical Development—Separation Sciences in Massachusetts. You will independently plan and execute routine and moderately complex experiments, analyze data, and contribute to technical documents and project deliverables.

You will work on separation-based analytics for biologics, using chromatographic and electrophoretic methods, and support method development, transfer, and QC readiness with cross-functional teams.

Qualifications

• Hands-on laboratory experience.
• Experience with separation-based analytical methods for biologics.
• Familiarity with listed chromatographic techniques and glycan analysis.
• Knowledge of chromatography instrumentation and digital systems.
• Understanding of biologics quality attributes and data integrity.
• Ability to document results with good GMP practices.

Responsibilities

• Plan, execute, and document chromatography-based experiments for biologics.
• Contribute to method development, qualification, validation, and transfer.
• Prepare protocols, lab records, and technical reports for regulatory submissions.
• Coordinate internal/external testing and communicate data clearly.
• Identify issues and propose corrective actions with cross-functional teams.

Skills

Separation-based analytics

Chromatographic methods

Data interpretation

Cross-functional collaboration

Troubleshooting

GMP knowledge

Education

Associate degree (4+ years)

Bachelor’s degree (2+ years)

Master’s degree (0+ years)

Tools

SEC-HPLC

IEX-HPLC

RP-HPLC

HIC-HPLC

UPLC

CE-SDS

icIEF

cIEF

Glycan analysis

Chromatography data systems

ELN

LIMS

Job description

Join Takeda as a Senior Research Associate, Analytical Development—Separation Sciences. You work independently on assignments with defined objectives and general direction, planning and executing routine and moderately complex experiments, analyzing and interpreting data, and contributing to technical documents and project deliverables.

About the role

• Contribute to separation-based analytical activities supporting biologics development, quality control readiness, method transfer, process/product understanding, comparability, stability, and regulatory submissions.
• Independently plan, execute, analyze, and document experiments using chromatographic and electrophoretic methods for biologics (e.g., monoclonal antibodies, bispecifics, therapeutic proteins).
• Design and perform analytical/biophysical studies to assess structure, heterogeneity, purity, stability, degradation pathways, PTMs, higher-order structure, and product-related variants.
• Perform chromatographic/electrophoretic analyses (SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS, icIEF, cIEF, glycan analysis, etc.).
• Support method development/optimization/qualification/validation/transfer/lifecycle management and QC readiness.
• Prepare/review protocols, lab records, technical reports, data summaries, SOPs, and technology transfer documentation; use electronic systems and software tools.
• Identify/communicate technical issues and propose solutions (with supervisor support); coordinate internal/external testing as assigned.

What you bring to Takeda

• Associate degree (4+ years), bachelor’s (2+ years), or master’s (0+ years) in analytical chemistry/biochemistry/protein chemistry/biologics analytical development/quality control or related.
• Required: hands-on laboratory experience.
• Experience with separation-based analytical methods for biologics/proteins/peptides.
• Practical knowledge of one or more relevant methods (SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS, icIEF, cIEF, glycan analysis, etc.).
• Experience with analytical instrumentation and digital systems (chromatography data systems, ELN, LIMS).
• Understanding of biologics quality attributes; ability to execute experiments, interpret data, and communicate results clearly.
• Ability to prepare/review technical documentation; knowledge of good documentation practices, data integrity, lab safety, and basic GMP.
• Ability to troubleshoot, propose solutions, and work across cross-functional teams.