Senior Research Associate, Analytical Development - Separation Sciences

Takeda; Lexington (VA); On-site; USD 90,000 - 141,000; Full time

Job summary

Takeda in Lexington, MA is seeking a Senior Research Associate in Analytical Development–Separation Sciences. You will independently design, execute, and document separation-based experiments for biologics, including monoclonal antibodies and other therapeutic proteins, using SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS, icIEF, and cIEF.

You will collaborate with Process Development, Quality, Regulatory, and Manufacturing Sciences to generate high-quality data, troubleshoot issues, and

Qualifications

• Associate degree with 4+ years, bachelor’s degree with 2+ years, or master’s degree with 0+ years of relevant industry experience in analytical chemistry, biochemistry, protein chemistry, biologics analytical development, quality control, or a related discipline.
• Previous hands-on experience working in a laboratory setting is required.
• Experience with separation-based analytical methods for biologics, proteins, peptides, or related complex molecules.

Responsibilities

• Independently design, plan, execute, analyze, and document routine, moderately complex, and selected advanced separation sciences experiments under general direction.
• Perform analytical and biophysical studies to assess biologics structure, heterogeneity, purity, stability, degradation pathways, and product-related variants.
• Apply methods such as SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS, icIEF, cIEF, glycan analysis, and related separation-based techniques.
• Support method development, method optimization, qualification, validation, transfer, troubleshooting, lifecycle management, and QC readiness activities.
• Prepare and review experimental protocols, laboratory records, technical reports, data summaries, method documents, SOPs, and technology transfer documentation.

Skills

Analytical chemistry

Biochemistry

Biologics analytics

Laboratory techniques

Education

Associate degree

Bachelor’s degree

Master’s degree

Tools

SEC-HPLC

IEX-HPLC

RP-HPLC

HIC-HPLC

UPLC

CE-SDS

icIEF

cIEF

glycan analysis

LIMS

Job description

Job Description

Join Takeda as a Senior Research Associate, Analytical Development-Separation Sciences, you work independently on assignments with definedobjectivesand general direction. You plan and execute most routine and moderately complex experiments, analyze and interpret data using established procedures, and contribute to technical documents and project deliverables. You apply judgment within defined procedures and policies,identifyand communicate technical issues, and propose solutions with supervisor support. You build productive relationships within the department and acrossPharmScifunctions, contribute to project execution, and mayprovideinformal technical guidance to junior colleagues

About the role:

The Senior Research Associate is responsible for contributing to separation-based analytical activities supportingbiologicsdevelopment, quality control readiness, method transfer, process and product understanding, comparability, stability, and regulatory submissions. You will independently plan, execute, analyze, and document routine and moderately complex experiments using chromatographic and electrophoretic methods for biologics, including monoclonal antibodies,bispecific, and other therapeutic proteins.You will work with departmental and cross-functional partners to generate high-quality data, troubleshoot technical issues, and support analytical deliverables for CMC programs. You will bring hands-on laboratory experience, strong documentation practices, technical curiosity, and the ability to develop deeper expertise in separation sciences methods such as U/HPLC, SEC, IEX, RP, HIC, CE-SDS,icIEF,cIEF, glycan profiling, or related analytical technologies. This role does not includepeopleleadership or people management responsibilities.

How you will contribute:

• Independently design, plan, execute, analyze, and document routine, moderately complex, and selected advanced separation sciences experiments under general direction.Perform analytical and biophysical studies to assess biologics structure, heterogeneity, purity, stability, degradation pathways, post-translational modifications, higher-order structure, and product-related variants.

• Perform chromatographic and electrophoretic analyses to assess biologics purity, heterogeneity, charge variants, size variants, glycan profiles, product-related variants, degradation products, and stability-indicating attributes.Apply methods such as SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS,icIEF,cIEF, glycan analysis, and related separation-based techniques.

• Support method development, method optimization, qualification, validation, transfer, troubleshooting, lifecycle management, and QC readiness activities.

• Prepare and review experimental protocols, laboratory records, technical reports, data summaries, method documents, SOPs, and technology transfer documentation.Collect, manage, analyze, interpret, and summarize data using established procedures, electronic systems, and scientific software tools.

• Identifyand communicate technical issues related to methods, samples, instruments, data analysis, documentation, software, or vendors, and propose practical solutions with supervisor support.

• Contribute to project activities across one or morebiologicsprograms, including stability, comparability, process development, formulation development, manufacturing support, and regulatory submission support.

• Work with departmental colleagues and cross-functional partners, including Process Development, Quality, Regulatory, Manufacturing Sciences, QC, and external laboratories, to support project timelines and analytical deliverables.

• Coordinate defined internal or external testing activities, including sample coordination, data package review, and consolidation of results, as assigned.

• Communicate experimental results, technical observations, and risks clearly to supervisors, project leads, departmental colleagues, and cross-functional partners.

• Maintainhigh standardsfor laboratory safety, data integrity, good documentation practices, GMP awareness, and compliance with applicable procedures.

• Support continuous improvement of laboratory workflows, data review practices, method execution, documentation, and analytical processes.

• Serve as a technical resource for selected instruments, methods, or laboratory workflows, and may train or mentor colleagues, interns, or co-ops.

• Stay current with relevant separation sciences technologies, biologics analytical methods, digital tools, and regulatory expectations.

What you bring to Takeda:

• Associate degree with 4+ years, bachelor’s degree with 2+ years, or master’s degree with 0+ years of relevant industry experience in analytical chemistry, biochemistry, protein chemistry, biologics analytical development, quality control, or a related discipline.

• Previoushands-on experience working in a laboratory setting isrequired.

• Experience with separation-based analytical methods for biologics, proteins, peptides, or related complex molecules.

• Practical knowledge of one or more relevant methods such as SEC-HPLC, IEX-HPLC, RP-HPLC, HIC-HPLC, UPLC, CE-SDS,icIEF,cIEF, glycan analysis, or related techniques.

• Experience with analytical instrumentation, chromatography data systems, electronic laboratory notebooks, LIMS, or related digital laboratory systems.

• Working understandingofbiologicsquality attributes, including purity, heterogeneity, charge variants, size variants, product-related variants, degradation products, and stability-indicating attributes.

• Ability to independently execute experiments, analyze data, interpret results, and communicate conclusions within established procedures and project expectations.

• Ability to prepare and review technical documentation, including protocols, reports, data summaries, method documents, SOPs, and transfer materials.

• Understanding ofgood documentation practices, data integrity principles, laboratory safety, and basic GMP expectations.

• Ability to troubleshoot technical issues, propose practical solutions, and escalate risks appropriately.

• Ability to work across departmental and cross-functional teams with an understanding of project timelines, deliverables, and data quality expectations.

• Ability to manage multiple assignments with general direction whilemaintainingattention to scientific quality, timelines, and documentation standards.

• Ability to communicate technical information clearly in writing, in meetings, and in scientific discussions.

• Comfort using digital and AI-enabled tools to support data analysis, workflow improvements, documentation, and scientific decision-making.

• Ability to work independently while contributing effectivelyina multidisciplinary team environment.

Important Considerations:

At Takeda, our patients rely on us to deliver quality products. As a result, we must follow strict rules in our manufacturing facilities to ensure we are not endangering the quality of the product. In this role, you may:

• Work in a controlled environment requiring special gowning and wear protective clothing over the head, face, hands, feet and body. This may include additional hearing protection for loud areas.
• Need to remove all make-up, jewelry, contact lenses, nail polish and/or artificial fingernails while in the manufacturing environment.
• Work in a cold, wet environment.
• Work multiple shifts, including weekends, or be asked to work supplemental hours, as necessary.
• Work around chemicals such as alcohol, acids, buffers and Celite that may require respiratory protection.

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

#GMSGQ #ZR1 #LI-MA1

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Lexington, MA

U.S. Base Salary Range:

$89,900.00 - $141,240.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Lexington, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.