Senior Research Associate

Cabaletta Bio; Philadelphia (Philadelphia County); On-site; USD 85,000 - 125,000; Full time

Benefits offered by this job

Stock options

PTO

Competitive benefits

Job summary

Cabaletta Bio is seeking a Research Associate/Sr. Research Associate for our Preclinical Research team in Philadelphia, on-site. You will conduct cell-based assays, generate and maintain cell lines, and perform IND-enabling work under supervision.

The role offers exposure to molecular biology and immunology applications in cell therapy development. The position emphasizes meticulous record-keeping, adaptation to new techniques, and collaborative work in a growing biotech environment at Cabaletta

Qualifications

• Must have MS in Biology or Bioengineering (or related field) with 0–3 years experience, or a bachelor’s with 2–4+ years in biotech.
• General lab skills including aseptic techniques and handling human tissue.
• Experience in mammalian cell culture, media prep, and cell bank management.
• Flexible, highly organized, able to work independently with training.
• Strong written communication and excellent record-keeping.

Responsibilities

• Maintain, bank, and manage diverse cell lines including primary cells.
• Generate cell lines using lentivirus for suspension cells.
• Perform cytotoxicity and other cell-based assays.
• Execute IND-enabling assays per SOPs and proper documentation.
• Follow cGLP and lab safety policies and SOPs; maintain records.

Skills

Cell culture

Aseptic technique

Record-keeping

Independent work

Written communication

Education

MS in Biology or Bioengineering

Bachelor's degree + 2-4+ years biotech

Tools

Lentivirus technology

Mammalian cell handling

Flow cytometry (preferred)

Job description

Position Title: Research Associate/Sr. Research Associate

Location: On-Site/Philadelphia, PA

Department: Preclinical

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese‑cel, a 4‑1BB‑containing fully human CD19‑CAR T cell investigational therapy. Rese‑cel is currently being evaluated in the RESET™ (REstoring SElf‑Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

About The Position

Reporting to Senior Scientist, Cellular Immunology, Preclinical Research, we are seeking an experienced, motivated, detail-oriented, and highly skilled Research Associate/Sr. Research Associate to join our preclinical research team. Under scientific and technical supervision, the individual will perform various cell-based assays and other in vitro and ex vivo based assays to contribute to the discovery and development of novel therapeutics at Cabaletta. Additionally, the individual will be responsible for cell line generation and maintenance to assist in the development of novel cell-based assays for the Cellular Immunology team. The position allows for potential impact in additional areas within Cabaletta, including molecular biology, immunology, and cell therapy development.

Responsibilities

• Maintain and expand, bank, and manage various cell lines, including primary cells
• Cell line generation using lentivirus technology for suspension cell lines.
• Perform cytotoxicity and other cell-based assays
• Perform IND-enabling assays following SOPs and proper documentation
• Perform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies and SOPs.
• Maintain accurate and well-organized records and electronic laboratory notebook.
• Actively contribute to process improvements and the implementation of new technologies.
• Perform flow cytometry assays

Required Qualifications

• MS degree in Biology or Bioengineering (or related field) with 0-3 years of experience, or bachelor’s degree with 2-4+ years of experience in the biotechnology industry required.
• General lab skills, including aseptic techniques and human tissue handling required
• Lab experience and expertise in mammalian cell husbandry required, including maintaining cell cultures with good aseptic technique, media preparation, and generating/managing cell banks
• A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise
• Must be highly organized, have excellent attention to detail, and be able to work independently with training
• Must be able to clearly communicate in writing and have excellent record-keeping skills

Preferred Qualifications

• Experience in primary cell and iPSC-derived cell culture desired
• Strong team orientation and passion for continuous self-development
• Experience in industry or in a startup industrial setting is preferred, including knowledge of good documentation practices
• Previous experience with flow cytometry is not required but would be a plus
• Must have a desire to be part of a growing organization that uses cutting-edge science

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.