Research Associate/Sr. Research Associate

Cabaletta Bio; Philadelphia (Philadelphia County); On-site; USD 60,000 - 95,000; Full time

Benefits offered by this job

Health and retirement benefits

PTO

Stock option plans

Job summary

Cabaletta Bio is seeking a Research Associate/Sr. Research Associate for preclinical research in Philadelphia. You will perform cell-based assays, develop and maintain cell lines, and contribute to assay development under supervision.

The role involves handling mammalian cells, applying aseptic techniques, and documenting results carefully. Opportunities span molecular biology and immunology while supporting growth and innovation at Cabaletta Bio.

Qualifications

• MS degree in Biology or Bioengineering (or related field) with 0-3 years experience, or BA/BS with 2-4+ years in biotech.
• Aseptic techniques and human tissue handling required.
• Mammalian cell culture husbandry and cell banking experience preferred.
• Strong organizational skills and ability to work independently with training.
• Clear written communication and meticulous record-keeping.

Responsibilities

• Maintain, bank, and manage various cell lines including primary cells.
• Generate cell lines using lentivirus for suspension cell lines.
• Perform cytotoxicity and other cell-based assays.
• Carry out IND-enabling assays following SOPs and documentation.
• Follow cGLP and Cabaletta Bio lab safety policies and SOPs; maintain records.

Skills

General lab skills

Mammalian cell culture

Record-keeping

Independent work

Communication

Education

MS degree in Biology or Bioengineering (or related field)

Bachelor’s degree with 2-4+ years in biotech

Tools

Lentivirus-based cell line generation

Flow cytometry (preferred)

General cell culture facilities

Job description

On-Site/Philadelphia, PA

About the Position

Reporting to Senior Scientist, Cellular Immunology, Preclinical Research, we are seeking an experienced, motivated, detail-oriented, and highly skilled Research Associate/Sr. Research Associate to join our preclinical research team. Under scientific and technical supervision, the individual will perform various cell-based assays and other in vitro and ex vivo based assays to contribute to the discovery and development of novel therapeutics at Cabaletta. Additionally, the individual will be responsible for cell line generation and maintenance to assist in the development of novel cell-based assays for the Cellular Immunology team. The position allows for potential impact in additional areas within Cabaletta, including molecular biology, immunology, and cell therapy development.

Responsibilities Include

• Maintain and expand, bank, and manage various cell lines, including primary cells
• Cell line generation using lentivirus technology for suspension cell lines.
• Perform cytotoxicity and other cell-based assays
• Perform IND-enabling assays following SOPs and proper documentation
• Perform lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies and SOPs.
• Maintain accurate and well-organized records and electronic laboratory notebook.
• Actively contribute to process improvements and the implementation of new technologies.
• Perform flow cytometry assays

Required Qualifications

• MS degree in Biology or Bioengineering (or related field) with 0-3 years of experience, or bachelor’s degree with 2-4+ years of experience in the biotechnology industry required.
• General lab skills, including aseptic techniques and human tissue handling required
• Lab experience and expertise in mammalian cell husbandry required, including maintaining cell cultures with good aseptic technique, media preparation, and generating/managing cell banks
• A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise
• Must be highly organized, have excellent attention to detail, and be able to work independently with training
• Must be able to clearly communicate in writing and have excellent record-keeping skills

Preferred Qualifications:

• Experience in primary cell and iPSC-derived cell culture desired
• Strong team orientation and passion for continuous self-development
• Experience in industry or in a startup industrial setting is preferred, including knowledge of good documentation practices
• Previous experience with flow cytometry is not required but would be a plus
• Must have a desire to be part of a growing organization that uses cutting-edge science

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.