Senior Quantitative Pharmacologist

Regeneron Pharmaceuticals, Inc (USA); Village of Tarrytown (NY); Hybrid; USD 129,000 - 210,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc (USA) seeks a Senior Quantitative Pharmacologist to contribute to Pharmacometrics deliverables across multiple programs and shape strategic positioning within PMx and the broader organization.

The role involves applying PK/PD analyses, population PK/PD, exposure–response, and mechanistic modeling to support development decisions and regulatory interactions.

Qualifications

• PhD in Quantitative Pharmacology, Pharmacometrics, Engineering, or a related field with 3+ years of experience.
• Hands-on experience with PK/PD modeling, population PK/PD, exposure–response, or mechanistic modeling (systems biology, or QSP).
• Proven ability to apply quantitative methods to drug development and regulatory submissions.

Responsibilities

• Collaborate to plan, design, implement, and analyze PMx studies across programs.
• Apply standardized analyses (NCA, compartmental, population PK/PD) and translate results into recommendations.
• Prepare reports, technical summaries, and regulatory submission documents.
• Contribute PMx expertise in cross-functional teams and regulatory discussions.

Skills

PK/PD Modeling

Population PK/PD

Exposure‑Response

Systems Biology

QSP

Education

PhD in Quantitative Pharmacology/Pharmacometrics/Engineering

Tools

NONMEM

Monolix

Simulx

MATLAB/SimBiology

R

Job description

Build Our Future Together As a Senior Quantitative Pharmacologist this individual is expected to provide significant contributions to Pharmacometrics deliverables in support of multiple programs while also developing an ability to understand the strategic positioning for these programs in Pharmacometrics as well as across the organization. Through the application of state-of-the-art knowledge in pharmacokinetics and pharmacodynamics; is responsible for the execution of PK, PD, and other types of quantitative analyses that significantly contribute to the development of multiple programs.

When & where: Work Location: Tarrytown, NY, Warren, NJ, Cambridge, MA Work model/flexibility: 4 days per week onsite or remote Discover your role: Collaborate across functions to plan, design, implement, and analyze pharmacometrics (PMx) studies supporting drug development programs.

Apply standardized scientific approaches to evaluate and interpret in vitro and in vivo pharmacokinetic (PK), pharmacodynamic (PD), and PK/PD data. Conduct a broad range of quantitative analyses including NCA, compartmental modeling, population PK, exposure-response, translational, and disease modeling. Interpret study results and develop scientifically sound conclusions and recommendations to support development decisions. Prepare accurate, timely, and well-articulated study reports, technical summaries, and regulatory submission documents.

Partner with PMx Research Specialists, programmers, statisticians, and scientific writers to develop tables, figures, listings (TFLs), and supporting analyses for internal and regulatory deliverables. Contribute PMx expertise to Research and Global Clinical Study Team (GCST) meetings, including input on study design, analysis strategy, and interpretation of results. Support regulatory interactions by preparing analyses and background materials for agency meetings, including pre-IND, End-of-Phase 2, and pre-BLA submissions. Monitor project timelines, deliverables, and completion of assigned tasks; may serve as the PMx representative on cross-functional development teams with appropriate guidance.

Maintain compliance with PMx operating procedures, quality standards, and the company's code of ethical conduct. This role requires: PhD in Quantitative Pharmacology, Pharmacometrics, Engineering, or a related field with 3+ years of experience Demonstrated expertise in population PK/PD, exposure–response, or mechanistic modeling (systems biology, or QSP) using tools such as NONMEM, Monolix, Simulx, MATLAB/Simbiology and R. Hands‑on experience with a broad range of quantitative and computational tools and a strong publication record. Exceptional communication and interpersonal skills, with the ability to influence and partner effectively across technical and non-technical teams.

Does this sound like you? We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

Salary Range (annually) $128,600.00 - $210,000.00

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician‑scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA‑approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.

Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.