Senior Protein Formulation Scientist, Conjugates

JLSa2 Therapeutics; South San Francisco (CA); On-site; USD 175,000 - 200,000; Full time

Job summary

JLSa2 Therapeutics in South San Francisco seeks a Senior Protein & Peptide/Conjugate Formulation Scientist to lead development, optimization, and characterization of stable formulations for protein and peptide-drug conjugates. The role blends hands-on work with cross-functional leadership across developability and CMC decisions.

The candidate will contribute to IND-enabling work, regulatory documentation, and external collaborations, with 5–10 years of industry experience and a PhD in a related

Qualifications

• PhD in pharmaceutical sciences, chemical engineering, biochemistry, or related discipline.
• 5–10 years of industry experience in protein and/or peptide formulation.
• Deep expertise in biologics and drug-conjugates formulation and stability science.
• Experience with high-concentration formulations and/or long-acting injectables.
• Experience with oral delivery formulations.
• Proven track record supporting clinical candidates.
• Strong experimental design, data interpretation, and problem-solving skills.

Responsibilities

• Design and optimize formulations for proteins and peptide/chemical-protein conjugates (liquid, long-acting, oral, high-concentration).
• Develop formulation strategies addressing stability, aggregation, degradation, and delivery challenges.
• Support route of administration and dosage form selection for subcutaneous and oral routes.
• Lead formulation risk assessments and mitigation strategies.
• Mentor junior formulation and analytical scientists; establish best practices.

Skills

Biophysical characterization

Formulation design

Stability assessment

Technical leadership

Cross-functional collaboration

Education

PhD in pharmaceutical sciences or related

Tools

DSC

DLS

CD

SEC

Job description

JLSa2 Therapeutics in South San Francisco seeks a Senior Protein & Peptide/Conjugate Formulation Scientist to lead development, optimization, and characterization of stable formulations for protein and peptide-drug conjugates. The role blends hands-on work with cross-functional leadership across developability and CMC decisions.

The candidate will contribute to IND-enabling work, regulatory documentation, and external collaborations, with 5–10 years of industry experience and a PhD in a related