Senior Protein Chemist & Library Prep Lead

US Health Partners, LLC; San Carlos (CA); On-site; USD 180,000 - 280,000; Full time

Job summary

Nautilus is building a new proteomics sample preparation workflow and seeking a seasoned protein scientist to own the library prep end to end. You will design how proteins are prepared, labeled, and attached to our platform, ensuring robust, documented protocols that can be run by other teams.

You will work across assay development, probe development, and bioinformatics, defining quality metrics and driving responsible decisions based on data.

Qualifications

• PhD in biochemistry, chemistry, chemical biology, bioengineering, or a related field with 10+ years of industry experience; or BS/MS with 15+ years in a related field
• Deep hands-on expertise handling, purifying, and stabilizing proteins
• Demonstrated record of innovation in protein bioconjugation (e.g., site-selective labeling, click chemistry, crosslinkers, surface immobilization)
• Expert in protein characterization: mass spectrometry, SEC, DLS, CD, SDS-PAGE/native PAGE, and activity or binding assays
• Proven ability to take a workflow from concept to a robust, reproducible protocol used by other teams
• Exceptional experimental design and data analysis skills, including multi-factor experiments
• Track record of leading cross-functional technical work and influencing without authority
• Experience mentoring scientists and setting technical direction for a team

Responsibilities

• Own the proteomics sample preparation workflow end to end, from strategy and first experiments to a robust protocol others can run
• Lead development of bioconjugation strategies to label and immobilize proteins with minimal impact on protein integrity
• Build the characterization toolkit for every step: prove what's conjugated, what's intact, what's aggregated, and what was lost
• Set quality metrics and acceptance criteria for prepared protein samples libraries, and use them to make go/no-go calls
• Design complex, multi-factor experiments that give the program decisive direction
• Drive root cause and permanent corrective actions when the workflow fails
• Partner with assay, probe development, and bioinformatics teams to integrate library prep into the full workflow and interpret results together
• Present plans, results, and recommendations to the team and to R&D leadership
• Set technical direction for library prep, mentor scientists and associates, and weigh in on program-level tradeoffs

Job description

Nautilus is building a new proteomics sample preparation workflow and seeking a seasoned protein scientist to own the library prep end to end. You will design how proteins are prepared, labeled, and attached to our platform, ensuring robust, documented protocols that can be run by other teams.

You will work across assay development, probe development, and bioinformatics, defining quality metrics and driving responsible decisions based on data.