Lead Assay Scientist, Single-Molecule Proteomics Platform

US Health Partners, LLC; San Carlos (CA); Vor Ort; USD 140.000 - 210.000; Vollzeit

Zusammenfassung

Nautilus is developing a single-molecule proteomics platform. We seek a seasoned assay scientist to lead assay development and integration, taking chemistry from bench to instrument and ensuring reliable operation. You will own assay performance from first integration experiments to production-ready workflows.

You will collaborate with assay, probe development, engineering, and bioinformatics teams, design informative experiments, and help transfer methods to operations or manufacturing.

Qualifikationen

• PhD or extensive industry experience in biochemistry, molecular biology, bioengineering, chemistry, or related field.
• Hands-on experience developing single-molecule assays and analysis techniques.
• Proven record of innovation in protein or molecular biology assays.
• Experience handling proteins including labeling, storage, and stability.
• Track record of integrating assays on complex instruments with integrated optics, fluidics, and workflows.
• Proficiency in Python for large dataset analysis.

Aufgaben

• Lead design and development of robust assays and reagents with simple, elegant workflows.
• Partner with library prep team to confirm assay reagents work on the platform.
• Define and develop control reagents to evaluate assay performance on the integrated system.
• Develop workflows to remove reagents after each binding cycle while keeping proteins on the platform intact.
• Design complex, information-rich experiments that give the program decisive direction.
• Solve integration problems across detection, fluidics, optics, surface chemistry, reagents, and software.
• Troubleshoot reagent and binding-cycle issues, drive root cause and permanent corrective actions.
• Lead failure analysis with engineering and bioinformatics, and drive performance improvements.
• Set assay performance metrics and acceptance criteria, and use them to make go/no-go calls.
• Analyze large datasets in Python, use bioinformatic pipelines, and turn results into recommendations for R&D leadership.

Kenntnisse

Single-molecule assays

Python data analysis

Experimental design

Protein handling

Cross-functional collaboration

Ausbildung

PhD in biochemistry/molecular biology/bioengineering/chemistry or related; or BS/MS with 15+ years experience

Tools

Bioinformatics pipelines

Assay integration on complex platforms

Jobbeschreibung

Nautilus is developing a single-molecule proteomics platform. We seek a seasoned assay scientist to lead assay development and integration, taking chemistry from bench to instrument and ensuring reliable operation. You will own assay performance from first integration experiments to production-ready workflows.

You will collaborate with assay, probe development, engineering, and bioinformatics teams, design informative experiments, and help transfer methods to operations or manufacturing.