Senior Process Engineer

Zeta Inc.; King of Prussia (PA); On-site; USD 130,000 - 170,000; Full time

Benefits offered by this job

Hybrid work model

Office in King of Prussia

Health benefits

401K with employer match

Job summary

ZETA is seeking a Senior Process Engineer in King of Prussia to lead process design and engineering activities for biopharmaceutical client projects. You will work across upstream, downstream, and cell and gene therapy applications, ensuring GMP-compliant solutions and collaboration across engineering teams.

The role requires a Bachelor's in Engineering, 10+ years in Biotech/Pharma, and knowledge of GMP requirements.

Qualifications

• Bachelor's degree in Engineering or related technical discipline.
• Minimum 10 years of experience in Biotech/Pharmaceutical industry.
• Knowledge of GMP requirements and biopharmaceutical process systems.

Responsibilities

• Lead process design and engineering activities for biopharmaceutical projects.
• Prepare and review process documentation (PFDs, P&IDs, mass/energy balances).
• Design process equipment such as vessels, mixing systems, filtration skids.

Skills

Process engineering

GMP compliance

Cross-functional collaboration

Biopharma knowledge

Education

Bachelor's degree in Engineering

Tools

PFD/ P&ID design

Job description

ZETA is a global engineering and technology partner serving pharmaceutical and biopharma companies. With over 30 years of experience, we specialize in process engineering, automation, and GMP-compliant systems to help deliver life-saving therapies.

Position Summary

The Senior Process Engineer is responsible for leading process design and engineering activities for ZETA's biopharmaceutical client projects. This role supports the development of process systems including upstream, downstream, blood plasma fractionation, ADCs, and cell and gene therapy applications. The Senior Process Engineer collaborates with cross-functional engineering teams to deliver high-quality, GMP-compliant solutions.

Location: King of Prussia Contract: Full-time employee Start: 27.10.2026

Duties and Responsibilities

• Accountable for delivering the process engineering scope on time, on budget, and in accordance with quality and compliance requirements.
• Prepare and review process engineering documentation, including PFDs, P&IDs, and mass/energy balances.
• Specify and design process equipment such as vessels, mixing systems, filtration skids, and related components.
• Develop User Requirements Specifications (URS) and Functional Specifications.
• Lead and execute start-up and commissioning activities including FAT and SAT.
• Provide process troubleshooting and technical support to internal and external stakeholders.
• Coordinate with automation, mechanical, and project management teams to ensure alignment across engineering disciplines.
• Develop CIP/SIP strategies, including cycle design, testing, and optimization.

Required Qualifications

• Bachelor's degree in Engineering or related technical discipline.
• Minimum 10 years of experience in the Biotech/Pharmaceutical industry.
• Knowledge of GMP requirements and biopharmaceutical process systems.

Preferred Qualifications

• Experience with bioprocess unit operations such as buffer/media prep, upstream, or downstream processing.
• Prior experience supporting capital projects.

Work Environment & Physical Requirements

• Hybrid work model with three onsite days per week at the King of Prussia office.
• Travel up to 30%, including domestic and international assignments as needed for project execution, FAT/SAT, or client support.
• Ability to work in an office, client sites, and manufacturing environments as needed.

Free coffee & Teas

Medical, Dental, & Vision Health Benefits & HSA & Short-term Disability

European-style PTO & vacation

401K with 5% employer match of annual salary