Senior / Principal Scientist, Phage & Yeast Display

Proclinical Staffing; Boston (MA); On-site; USD 80,000 - 140,000; Full time

Job summary

An innovative firm is seeking a Senior/Principal Scientist in Antibody Engineering to drive the discovery of next-generation antibody therapeutics. In this pivotal role, you will lead the development of cutting-edge display platforms, design and optimize diverse antibody libraries, and collaborate with multidisciplinary teams to advance therapeutic candidates. This position offers the opportunity to make a significant impact in the biotechnology sector, working at the forefront of healthcare innovation. If you are passionate about protein engineering and eager to contribute to groundbreaking research, this role is perfect for you.

Qualifications

• Proven expertise in display technologies and antibody discovery.
• Strong publication record in protein engineering.

Responsibilities

• Lead development of display platforms for antibody engineering.
• Design and screen diverse antibody libraries.
• Collaborate with cross-functional teams to advance therapeutic candidates.

Skills

PhD in biochemistry

5+ years of hands-on industry experience

Expertise in yeast and phage display platforms

Antibody discovery

Molecular biology techniques

Analytical skills

Communication skills

Education

PhD in biochemistry or related field

Tools

FACS

NGS

Deep mutational scanning

Job description

Senior / Principal Scientist - Permanent - Boston MA

Are you ready to make a groundbreaking impact in the world of biotechnology? Join a growing company that's shaping the future of healthcare and science.

Proclinical is seeking a dedicated Senior/Principal Scientist in Antibody Engineering and Phage/Yeast Display to join a dynamic team focused on the discovery of next generation targeted antibody therapeutics.

Skills & Requirements:

• PhD in biochemistry, protein engineering, chemical engineering or related field
• 5+ years of hands-on industry experience using display technologies
• Proven expertise in yeast and phage display platforms, as exemplified by a strong publication record
• Track record of success in antibody discovery, from immunization to library design, hit selection,humanization, and optimization
• Experience with immune and/or synthetic library generation and screening
• Proficiency with standard molecular biology techniques and protein expression systems
• Outstanding analytical, research and organizational skills
• Self-motivated with an ability to handle multiple projects, meet deadlines and make decisions
• Excellent oral and written communication skills

The Senior / Principal Scientist's responsibilities will be:

• Lead the development and optimization of display platforms (phage and yeast) for antibody and protein engineering applications
• Design, build and screen diverse immune and synthetic antibody libraries including monoclonals, antibody fragments, nanobodies and other novel antibody modalities
• Apply strategies for antibody affinity maturation and functional optimization
• Implement and refine high throughput screening workflows, including FACS, NGS and deep mutational scanning
• Analyze data to identify lead molecules and guide engineering decisions
• Collaborate with cross-functional teams, including Protein Science, Neuroscience, and Bioinformatics to advance platforms and therapeutic candidates
• Stay current with advances in protein/antibody engineering and display technologies
• Contribute to patent filings, publications, and external presentations

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at [e-mail]

If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.

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