Senior Scientist/Principal Scientist, Biotherapeutic Engineering

Atlas Venture; Waltham (MA); On-site; USD 80,000 - 150,000; Full time

Job summary

An innovative biotechnology company is seeking a Senior Scientist/Principal Scientist in Biotherapeutics Engineering. This role focuses on designing and optimizing biologics-based drugs, leveraging expertise in structural biology and molecular biology. The ideal candidate will lead cross-functional teams and apply advanced techniques to enhance biotherapeutics. With a commitment to improving patient outcomes, this position offers a unique opportunity to contribute to groundbreaking cancer therapies in a collaborative environment. Join a passionate team dedicated to making a difference in the lives of patients through cutting-edge science.

Qualifications

• 8-15 years of industry experience for BS/MS or 3-9 years for PhD.
• Expertise in biotherapeutics design and molecular biology.
• Strong background in structural biology and protein engineering.

Responsibilities

• Design and generate complex biologics for preclinical validation.
• Analyze protein structures and perform biophysical characterization.
• Lead research project teams and support IND filings.

Skills

Biotherapeutics Design

Protein Engineering

Antibody Discovery

Machine Learning Techniques

Molecular Biology

Analytical Skills

Problem-Solving Skills

Leadership Skills

Communication Skills

Organizational Skills

Education

BS/MS in Biochemistry

PhD in Structural Biology

Chemical and Biomolecular Engineering

Tools

CCG-MOE

Schrodinger-Maestro

Electronic Lab Notebooks (Benchling)

SPR Techniques

Job description

Senior Scientist/Principal Scientist, Biotherapeutic Engineering

• Company Address: 828 Winter St, Waltham, Massachusetts 02451, US

About Xilio Therapeutics

Focused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.

Job Description

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company uses its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more at www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

Summary

We are seeking a highly skilled and experienced Senior Scientist/Principal Scientist in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise and molecular biology methods. The ideal candidate will have a strong background in structural biology, protein engineering, and antibody discovery workflows. Experience applying machine learning techniques and molecular modeling to improve biotherapeutics' biophysical and biological properties is desirable. The candidate should have experience leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC).

Job Responsibilities

1. Design and generate complex biologics and multi-specific formats for preclinical validation.
2. Analyze protein structures to rationally design biologics.
3. Perform biochemical and biophysical characterization of engineered proteins to examine function and develop structure-function relationships.
4. Support antibody discovery and in-house yeast/phage display.
5. Apply state-of-the-art in silico biotherapeutic engineering tools, such as CCG-MOE or Schrodinger-Maestro, to design and optimize biologics.
6. Lead or co-lead research project teams, defining strategy and ensuring effective execution to meet goals and timelines.
7. Represent Protein Engineering at project team meetings.
8. Support writing and reporting for IND filings.
9. Maintain detailed experimental records in electronic lab notebooks (ELN).

Skills, Qualifications, and Requirements

• BS/MS or PhD in Biochemistry, Structural Biology, Chemical and Biomolecular Engineering, or related fields, with 8-15 years (BS/MS) or 3-9 years (PhD) of relevant industry experience.
• Expertise in biotherapeutics design, engineering, and molecular biology.
• Strong analytical and problem-solving skills for computational analysis of protein and DNA sequences.
• Background in structural biology is highly preferred.
• Experience with biophysical characterization techniques, including SPR, is strongly desired.
• Knowledge of yeast/phage display and antibody discovery is a plus.
• Familiarity with electronic lab notebooks like Benchling is preferred.
• Experience with CRO project management is highly valued.
• Excellent leadership and communication skills for leading teams and collaborating with stakeholders.
• Strong organizational skills to multitask in a fast-paced environment with changing priorities.

Equal Opportunity and Inclusion

We are committed to equal opportunity and inclusion in all aspects of our organization, including recruitment, advancement, and development practices. We conduct annual performance and development reviews, survey employee engagement, and provide allowances and time for professional development activities.