FL108 | Boston, MA (Senior) Scientist, Bioconjugation & Protein Sciences

Flagship Pioneering; Boston (MA); On-site; USD 80,000 - 150,000; Full time

Job summary

Join a pioneering biotechnology firm as a (Senior) Scientist in Protein Sciences, where you will drive innovation in protein conjugation and production. This role offers the opportunity to lead projects that enhance therapeutic solutions through advanced bioconjugation techniques. You'll collaborate with a multidisciplinary team to establish in-house capabilities and manage relationships with external partners. If you are passionate about transforming human health and thrive in a dynamic environment, this is the perfect opportunity to make a significant impact in the biotech field.

Qualifications

• Ph.D. or industry experience in chemistry or biochemistry is required.
• Prior experience in bioconjugation and protein purification techniques is essential.

Responsibilities

• Lead projects on protein conjugation and production.
• Collaborate with biology team for experimental design and execution.

Skills

Bioconjugation

Protein Purification Techniques

Analytical Skills

Problem-Solving Skills

Communication Skills

Attention to Detail

Team Collaboration

Education

Ph.D. in Chemistry, Biochemistry, or related field

Industry Experience in Protein Sciences

Tools

Affinity Chromatography

Size-Exclusion Chromatography

Ion-Exchange Chromatography

Job description

Boston, MA USA

Company Summary

FL108 Inc., is a privately held, early-stage biotechnology company developing a groundbreaking delivery technology platform. FL108 is focusing on designing and testing protein-based delivery modalities. Our vision is to enable targeting and internalization of a variety of payloads. FL108 is backed by Flagship Pioneering, bringing the vision and resources to guide FL108 from platform validation to real-world solutions that meaningfully improve patient care.

Role Summary

We are seeking a dedicated (Senior) Scientist, Protein Sciences to join our team. The role will focus on protein conjugation and production. Familiarity with AOC and ADCs is a plus, and industry experience in bioconjugation is a must.

Key Responsibilities

• Lead and manage projects focused on protein conjugation, production, and purification.
• Design and optimize protein conjugation strategies for a variety of molecules (antibodies, peptides, oligonucleotides), including linker design.
• Establish in-house conjugation, purification, and characterization capabilities.
• Collaborate with the biology team to design controlled experiments, align on handoffs, and required materials.
• Establish and manage CRO relationships to support protein-conjugates and linker production.
• Stay current with the latest scientific advancements and integrate new techniques and technologies into the research workflow.

Qualifications/Experience

• Scientific training (Ph.D. or industry experience) in chemistry, biochemistry, protein sciences, antibody engineering, or related field.
• Prior industry experience with bioconjugation is a must, with a preference for antibody bioconjugation.
• Experience with protein purification techniques (affinity chromatography, size-exclusion, ion-exchange) and with protein characterization and analysis methods is a must.
• Ability to work independently and as part of a team in a fast-paced environment with strong analytical and problem-solving skills, with attention to detail.
• Excellent written and verbal communication skills to effectively present results and scientific data to team leaders, cross-functional teams, academic collaborators, or partners.
• Self-motivated, highly organized, detail-oriented, and enthusiastic about playing a pivotal role in a dynamic and multidisciplinary small biotech environment.
• Experience or foundational knowledge in AOC and ADC state-of-the-art linkers.
• Experience with rational antibody design and screening techniques: phage and yeast display, transgenic production, affinity maturation, etc.
• Experience with mammalian expression and characterization of antibodies and antibody fragments.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in the generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents, and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.