Senior Principal Scientist Integrated Technology, Computation & Experimental Biology

Amgen Inc.; South San Francisco (CA); On-site; USD 171,000 - 231,000; Full time

Job summary

Amgen Inc. seeks a Senior Principal Scientist Integrated Technology, Computation & Experimental Biology to lead discovery programs across inflammation research.

You will shape strategy, integrate experimental biology with computational science, and drive AI-enabled approaches to accelerate therapeutic discovery. You will collaborate across cross-functional teams, mentor scientists, and translate complex biology into scalable, data-driven experiments, ultimately advancing pipeline programs and

Qualifications

• Doctorate or professional degree with 3+ years in computational biology and multi-omics data integration.
• Alternatively, Master’s with 6 years of computational biology and multi-omics data integration.

Responsibilities

• Provide scientific leadership for discovery programs and cross-functional teams.
• Define therapeutic hypotheses and translate into computational analyses and experiments.
• Leverage AI-enabled approaches to synthesize data and identify mechanisms.
• Guide program strategy, milestones, and risk assessment.
• Identify emerging technologies to advance inflammation research.

Skills

computational biology

multi-omics data integration

leadership

cross-functional collaboration

experimental biology

inflammation biology

Education

PhD

PharmD

MD

Master's degree

Bachelor's degree

Tools

AI-enabled tools

agentic workflows

machine learning

data analysis software

Job description

Career Category Scientific Job Description

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Principal Scientist Integrated Technology, Computation & Experimental Biology

What you will do

Let’s do this. Let’s change the world. In this vital role you will serve as a senior scientific and technology leader across Inflammation Research. You will define and execute integrated strategies that connect human biology, computation, AI-enabled reasoning, preclinical models and experimental testing to improve the quality, speed, and scalability of therapeutic discovery.

Key Responsibilities

• Leadership: provide scientific leadership for discovery programs, technology platforms, and strategic initiatives that integrate experimental biology and computational science. Lead cross-functional teams, create clarity in a rapidly evolving environment, and connect expertise across the organization to deliver results in a timely manner.
• Disease biology: Define ambitious, human-biology-led therapeutic hypotheses and translate them into coordinated computational analyses and decisive experiments. More particularly, connect human genetics, multi-omics, single-cell and spatial data, clinical observations, electronic or real-world data where appropriate, and experimental evidence to identify therapeutically actionable mechanisms.
• Computational expertise: Leverage AI-enabled analytical approaches such as machine learning and agentic workflows to synthesize literature and internal data, identify therapeutic mechanisms, prioritize targets, understand variants biology, design experiments, and continuously refine scientific models. Partner deeply with computational/data scientists, engineers; preclinical, clinical and translational scientists and modality teams.
• Pipeline: Define and guide program strategy, milestone, experimental prioritization, risk assessment, and resolution of complex scientific and technical issues. Design, direct, analyze, and interpret rigorous experimental studies that interrogate target biology and support drug discovery. Be accountable for scientific quality and delivery against longer-term objectives
• Innovative Technology: Identify, evaluate, and implement emerging technologies that create a meaningful step change and scale up inflammation research, including in vivo perturbation screens, high-content imaging, functional genomics, phenotypic screens, advanced human tissue models, scalable perturbational systems for automation, and multimodal data integration. Recognize scientific, technological, and industry trends beyond the immediate area and translate them into actionable opportunities for programs, capabilities, and departmental strategy.
• Communication: Mentor and provide scientific and technical guidance to colleagues across functions, while fostering an inclusive, connected, curious, and high-performing culture. Communicate complex science, uncertainty, and recommendations effectively to project teams, senior leaders, governance forums, and external scientific audiences. Build external scientific and technological eminence through collaborations, conference participation, publications, patents, and other reviewed scientific or technical outputs.

What we expect of you

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of computational biology and multi-omics data integration experience OR Master’s degree and 6 years of computational biology and multi-omics data integration experience OR Bachelor’s degree and 8 years of computational biology and multi-omics data integration experience.

Preferred Qualifications

• Demonstrated ability to work independently with considerable latitude, establish objectives, integrate activities across projects, and make high-quality decisions within a function or department.
• Demonstrated excellence in project leadership and the ability to balance scientific rigor, strategic focus, urgency, adaptability, and operational execution.
• Experience leading cross-functional scientific teams or serving as a lead scientist or technological resource for programs, platforms, or capabilities.
• Broad knowledge of leading experimental and computational biology, while connecting adjacent innovation and technology areas.
• Demonstrated ability to integrate both experimental and computational approaches is required rather than operating primarily within a single discipline
• Track record of solving complex scientific problems through ingenuity, creativity, rigorous experimentation, quantitative reasoning, and integration of diverse evidence.
• Excellent written and verbal communication skills, including the ability to frame complex science, data limitations, uncertainty, and recommendations for technical and senior leadership audiences.
• Commitment to coaching and mentoring others, collegial behavior sharing knowledge, and building a connected, inclusive, and inspiring environment in which colleagues can thrive
• Deep expertise in inflammation, immunology, tissue biology, human disease biology, computational biology, preclinical models, systems biology, imaging, bioengineering, or a closely related field.
• Experience using AI-enabled tools, agentic workflows, advanced analytics, quantitative modeling, or multimodal data integration to generate and test biological hypotheses.
• Strong record of designing or applying human-relevant experimental systems, including primary cells, murine models, patient-derived tissues, organotypic models, co-cultures, perturbational systems, functional genomics, imaging, single-cell, spatial, or multi-omic approaches.
• Ability to identify where technology can create a step change in biological understanding and to convert promising concepts into robust, reproducible, and scalable research capabilities.
• Experience advancing drug discovery programs and connecting mechanisms to target selection, modality, biomarkers, translational strategy, clinical differentiation, and portfolio value.
• Evidence of scientific influence beyond an immediate team, such as cross-functional leadership, external collaborations, invited presentations, lead or senior authorship in publications, patents, or widely adopted technological methods.

What you can expect of us

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law. We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

170,568.65USD -230,769.35 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen