Senior Scientist - Cardiometabolic Disorders

Amgen Inc. (IR); Thousand Oaks (CA); On-site; USD 127,000 - 172,000; Full time

Job summary

Amgen Inc. in Thousand Oaks seeks a Senior Scientist focused on Cardiometabolic Disorders to lead biology research, identify therapeutic targets, and drive preclinical programs.

You will design mechanistic studies, conduct in vivo and in vitro experiments, and guide team members while collaborating across functions. The role emphasizes strong communication, data integrity, and leadership as you advance assets in the Cardiometabolic portfolio, with opportunities to publish and present at

Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
• Master’s degree and 3 years of experience in bone metabolism and bone disease OR Bachelor’s degree and 5 years of experience in bone metabolism and bone disease
• Strong target ideation capabilities and critical thinking for discovery of innovative medicines
• Exceptional in vivo and/or in vitro pharmacology skills with proper controls and reproducible data
• Technical mastery of molecular biology and cell-signaling techniques (immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, ELISA)
• Understanding of human genetics and genomic data mining a plus

Responsibilities

• Conceptualizing and proposing therapeutic targets for bone and cardiometabolic disease
• Designing and performing in vitro and in vivo experiments
• Data analysis and interpretation of results
• Communicating results through written and oral presentations
• Collaborating with cross-functional teams to advance therapeutic candidates
• Documenting studies in ELN notebooks and study reports
• Advising colleagues in areas of expertise

Skills

PhD/MD/PharmD

In vivo pharmacology

In vitro pharmacology

Data analysis

Education

PhD in bone biology

Master's with 3 yrs bone metabolism

Tools

Immunoblotting

Immunocytochemistry

RT-qPCR

ELISA

Job description

Senior Scientist - Cardiometabolic Disorders

What you will do Let’s do this. Let’s change the world. In this vital role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of drug discovery programs will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies. Critical thinking, ingenuity, the ability to independently design mechanistic studies and conduct reproducible in vivo and in vitro pharmacology studies with high technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical for this role. You will initially work at the bench and/or vivarium conducting in vivo and/or in vitro preclinical studies with a focus on osteoporosis and metabolic disease. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research. As part of the team, you will also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio.

Key Responsibilities

• Conceptualizing and proposing therapeutic targets for the treatment of bone disease and cardiometabolic disease
• Designing and performing in vitro and/or in vivo experiments
• Independently performing data analysis and interpreting results
• Communicating scientific results through written and oral presentations
• Collaborating with teams from other functions in the company to advance therapeutic candidates
• Documenting studies in electronic laboratory notebooks and study reports.
• Advising colleagues in areas of expertise

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of experience in bone metabolism and bone disease OR Bachelor’s degree and 5 years of experience in bone metabolism and bone disease

Preferred Qualifications

• PhD with postdoctoral experience in bone metabolism and metabolic disease (industry experience is strongly preferred)
• Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients
• Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data
• Technical mastery of general molecular biology and cell-signaling analysis techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA
• Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated
• Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders
• A strong ability to collaborate cross-functionally in a multidisciplinary environment is critical
• Capability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance
• Understanding of human genetics and genomic data mining for target identification are a plus
• A high level of commitment to ensuring data reproducibility and data integrity

What you can expect from us

• From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
• The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
• In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Sponsorship

Sponsorship for this role is not guaranteed.

Amgen is an Equal Opportunity employer

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Salary Range

127,121.75USD -171,988.25 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit https://www.amgen.com and follow us on https://www.twitter.com/amgen