Senior Principal Scientist I

Sanofi; Cambridge (MA); On-site; USD 147,000 - 213,000; Full time

Job summary

An innovative global healthcare company is seeking a Senior Principal Scientist I to accelerate drug discovery in oncology. This role involves analyzing complex datasets to identify targets for immuno-oncology therapies. You will collaborate with multidisciplinary teams, utilizing your expertise in bioinformatics and high-dimensional data analysis. With a focus on patient datasets and cutting-edge technologies, you will contribute to groundbreaking research that enhances patient outcomes. Join a forward-thinking team dedicated to pushing the boundaries of science and improving lives through collaboration and innovation.

Benefits

Health and Wellbeing Benefits

Career Development Opportunities

Comprehensive Rewards

Wellness Programs

Parental Leave

Qualifications

• 5+ years of experience in oncology or immunology.
• Proven expertise in analyzing large-scale biological data.
• Strong understanding of bioinformatics methods.

Responsibilities

• Support therapeutic programs and target discovery efforts.
• Develop computational strategies for disease characterization.
• Design algorithms for target identification and patient stratification.

Skills

Bioinformatics

R Programming

Python Programming

Data Analysis

Multi-modal Data Analysis

Communication Skills

Education

Ph.D. in Biology

Ph.D. in Statistics

Ph.D. in Biophysics

Ph.D. in Bioinformatics

Tools

NGS

Flow Cytometry

Immunoassays

Single-cell Sequencing

Proteomics

Job description

Senior Principal Scientist I page is loaded

Senior Principal Scientist I

Apply locations Cambridge, MA | Full time | Posted Yesterday | End Date: September 7, 2025 | Job requisition id R2798708

Job Title: Principal Scientist I

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

Sanofi Oncology Therapeutic Area is seeking an experienced computational biologist/bioinformatician to join our team with a focus on reprogramming the tumor microenvironment and immune system to treat tumors. This hands-on role will analyze patient datasets including bulk RNAseq, single cell RNAseq/CITEseq, and flow cytometry to identify cell types, signaling pathways, and targets for overcoming immunosuppression.

You will work as an integral part of project teams in research and development to identify targets, understand compound activities, and develop and test actionable biomarker strategies for immuno-oncology programs. You will analyze patient genomic and transcriptomic data from internal studies, collaborations, and public sources to identify mechanisms and targets for immune-based, anti-cancer therapies. Designing, interpreting, and analyzing bulk and single cell NGS profiling experiments to characterize drug mechanisms and identify biomarkers will be key. You will present your work internally and externally through publications and presentations. The ability to work independently and collaboratively across disciplines is essential. This position is based within the Immuno-Oncology Cell Therapy Cluster in Cambridge, MA.

We are an innovative global healthcare company with a purpose: to chase the miracles of science to improve people’s lives. We offer opportunities to grow your career, explore new connections, and push your limits. Ready to get started?

Main Responsibilities

• Support multiple therapeutic programs and target discovery efforts, reporting directly to the Cluster Head.
• Develop and execute computational strategies for disease characterization from datasets to propose targets and drug combinations.
• Design and implement computational algorithms to analyze multi-omics, multi-modal, and high-content data for target identification, patient stratification, response prediction, and assay development.
• Create actionable biomarker plans (e.g., for selection, PD, efficacy biomarkers) and support knowledge transfer to Translational Medicine.
• Apply scientific expertise to design, direct, and analyze experiments supporting research programs.
• Engage proactively with colleagues across departments and disciplines.

About You

Basic Qualifications

• Ph.D. in biology, statistics, biophysics, or bioinformatics with emphasis on high-dimensional biological data analysis; at least 5 years of pharmaceutical or biotech experience in oncology, immunology, or related fields.
• Proven expertise in analyzing multi-modal, multi-dimensional, large-scale biological data, with a strong understanding of platforms like flow cytometry, immunoassays, NGS, single-cell sequencing, and proteomics.
• Experience using patient and preclinical NGS data for target selection or biomarker strategies.

• Expertise in Oncology or Immune-Oncology.
• Experience in multi-disciplinary collaborations.
• Proficiency in bioinformatics using R or Python.
• Knowledge of standard bioinformatic methods and reference datasets.
• Ability to work independently and with teams across research and Translational Medicine.

• Strong communication skills, both written and verbal.

Why Choose Us?

• Contribute to scientific miracles alongside a supportive, forward-looking team.
• Opportunities for growth and career development, domestically and internationally.
• Comprehensive rewards recognizing your contributions.
• Health and wellbeing benefits, including healthcare, wellness programs, and parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to diversity. All qualified applicants will receive consideration regardless of protected characteristics.

Pursue progress, discover extraordinary

Better science leads to better outcomes. Progress depends on diverse people working together to make miracles happen. Join us in this mission.

At Sanofi, we foster an inclusive environment and provide equal opportunities to all applicants.

Watch our ALL IN video and learn about our Diversity, Equity, and Inclusion initiatives at sanofi.com.

US and Puerto Rico Residents Only

The salary range for this position is $147,000 - $212,333.33. Compensation will be based on experience. Additional benefits are available, details at the provided link.