Senior Principal Scientist/Associate Director, Translational Development, Lung Cancer Disease Lead

Bristol Myers Squibb; Cambridge (MA); On-site; USD 119,000 - 271,000; Full time

Job summary

An innovative pharmaceutical company is seeking a Senior Principal Scientist to lead translational development in lung cancer. This pivotal role involves crafting strategies that bridge early and late-stage clinical development, ensuring effective collaboration across diverse teams. With a focus on groundbreaking research, you will leverage your expertise in human genetics and immunology to drive impactful projects that transform patient outcomes. Join a dynamic environment where your contributions will not only advance the science but also enhance the lives of patients globally. This is your chance to be part of a mission that truly matters.

Benefits

Competitive Benefits

Flexible Work Environment

Opportunities for Growth

Supportive Culture

Qualifications

• PhD in relevant field required with 6+ years of experience.
• Strong background in human genetics and immunology is essential.

Responsibilities

• Develop and execute translational disease strategy in lung cancer.
• Collaborate with cross-functional teams to drive research strategies.

Skills

Human Genetics

Cellular Biology

Immunology

Data Analysis

Clinical Trials

Education

PhD in Molecular Biology

PhD in Cancer Biology

Tools

Bioinformatics Software

Statistical Analysis Tools

Job description

Senior Principal Scientist/Associate Director, Translational Development, Lung Cancer Disease Lead

Senior Principal Scientist/Associate Director, Translational Development, Lung Cancer Disease Lead

2 days ago Be among the first 25 applicants

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more careers.bms.com/working-with-us .

Translational Medicine at BMS

Translational medicine is a department within the Research organization that facilitates the transition of drug candidates from early to late-stage clinical development, their approval and life cycle management. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action and disease segments.

Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage Translational Development function is responsible for the development of translational strategies to support the development, and maximize the potential, of BMS's therapies post-clinical proof-of-concept, including registrations and life-cycle management.

Translational disease strategies in solid tumor oncology are derived from long term investments in developing data and deep expertise in disease biology, patient segments, immunodeficiencies and of therapeutic resistance to assist science driven strategies for the development of the oncology pipeline.

Summary

Reporting to the Solid Tumor Lung Disease Head in Translational Medicine, the incumbent will be part of the translational group and will help develop translational disease strategies in lung cancer across multiple asset programs for approval or life-cycle management in the BMS pipeline. Key responsibility of this role is to effectively collaborate with a cross functional team of asset scientists with deep disease, drug development and business knowledge to help drive an overall translational strategy, working closely with discovery and early development teams, late clinical development as well as with our team of laboratory scientists.

Position Description

• Develops and executes translational disease strategy in lung disease area with deep disease expertise
• Leads and oversees execution of disease strategy including but not limited to various aspects of patient selection strategies
• Serves as scientific expert in generating novel hypotheses for targetable biologies based on novel discoveries integrating disease work with literature and deep expertise in lung biology
• Manages cross functional disease project teams with key interfaces in IT, bioinformatics, data sci, stats, external collaborators, contractors, other disease strategy leads and asset leads
• Maintains relationship with translational clinicians for identifying new opportunities and for gaining disease insight
• Identifies needs, gaps and translational disease questions and applies knowledge across all assets in BMS portfolio in lung area
• Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians
• Collaborate and guide bioinformatics partners on biological questions to deliver biomarkers and biological understanding from whole transcriptome, whole exome, and/or whole genome data, immune profiling and single cell data in order to support drug discovery and development in solid tumor oncology.
• Manage relationships with key internal stakeholders including regulatory, clinical and commercial and scientific communications and external collaborators to develop translational analysis plans and timelines, communicate analysis results.
• Represent the Solid Tumor Oncology Translational Development function at various internal meetings and provide domain knowledge and disease expertise to cross-functional teams.
• Direct and support publications in high quality scientific, technical or medical journals.
  
  

Qualifications

• PhD degree in a relevant field (e.g. molecular biology, cancer biology, human genetics, immunology).
• Minimum of 6 years post-PhD experience for Sr. Principal Level (and minimum of 8 years Post-PhD experience for AD Level), with demonstrated scientific leadership in integrating, analyzing, and interpreting multimodal biological data in an academic and/or industry setting.
• Strong background in human genetics/genomics, cellular biology, immunology or immuno-oncology, with an understanding of the tumor microenvironment, is required.
• Extensive knowledge of high-content biomarker platforms and good understanding of the current clinical practice in early and late stage lung cancer
• Ability to work in a fast-paced environment with rapidly changing and competing priorities and ambiguity.
• Strong team player with the ability to work in cross-functional teams. Excellent communication and collaboration skills.
• Prior experience with clinical trials preferred
• Strong track record of high-quality scientific publications in relevant fields
  
  

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail] . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information https //careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Pharmaceutical Manufacturing

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