Senior Principal Scientist — Computational Safety & AI Risk

Boehringer Ingelheim; Ridgefield (CT); On-site; USD 170,000 - 269,000; Full time

Job summary

Boehringer Ingelheim seeks a Senior Principal/Principal Scientist in Computational Safety to lead in silico safety assessments across drug discovery and development. This role uses multi-omics data, systems toxicology, and AI/ML to identify liabilities and support risk-based decisions.

You will partner with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science and IT to translate complex computational findings for diverse stakeholders.

Qualifications

• Ph.D. with 7+ years post-doc/industry experience in drug discovery and development.
• Experience in safety risk assessment and mechanistic modeling.

Responsibilities

• Lead in silico target safety assessment strategy development.
• Deliver integrated computational safety packages for program decisions.
• Advance AI/ML and multi-omics models for safety prediction.
• Drive AI-enabled AoP development for mechanistic risk assessment.
• Identify and communicate safety risks to stakeholders.
• Collaborate with Toxicology, Discovery, Clinical Safety and IT teams.
• Bridge complex computational insights to multidisciplinary audiences.

Skills

In silico safety

Computational toxicology

AI/ML modeling

Multi-omics data

Communication to stakeholders

Education

PhD in Computational Toxicology/Computational Biology/Bioinformatics/Molecular Biology or related

Tools

R

Python

ML frameworks

Job description

We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to proactively identify safety liabilities, support mechanistic understanding, improve quality target identification, and facilitate risk based decision making.

The Senior Principal Scientist/ Principal will play a key role in developing and delivering integrated computational safety strategies, including AI enabled foundation model based on multiple omics data, Adverse Outcome Pathways, off-target identification, and predictive liability models. Working closely with toxicologists, discovery scientists, clinical safety, bioinformatics, data science, and IT partners, this position will translate complex computational insights into clear, actionable recommendations that improve pipeline quality and reduce late stage attrition.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Description

We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to proactively identify safety liabilities, support mechanistic understanding, improve quality target identification, and facilitate risk based decision making.

The Senior Principal Scientist/ Principal will play a key role in developing and delivering integrated computational safety strategies, including AI enabled foundation model based on multiple omics data, Adverse Outcome Pathways, off-target identification, and predictive liability models. Working closely with toxicologists, discovery scientists, clinical safety, bioinformatics, data science, and IT partners, this position will translate complex computational insights into clear, actionable recommendations that improve pipeline quality and reduce late stage attrition.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• Lead and/or generate in silico target safety assessment strategy development
• Develop and deliver integrated computational safety packages to support program and portfolio decisions
• Advance AI/ML and multi omics–based models, including foundation models, for safety and liability prediction
• Drive AI enabled Adverse Outcome Pathway (AoP) development to support mechanistic risk assessment
• Proactively identify and communicate on target and off target safety risks
• Collaborate closely with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams
• Serve as a bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.

Requirements

Principal Scientist Requirements:
• 6+ years of post-doctoral and/or industry experience in drug discovery and development and ≥1 years of experience in safety risk assessment is a must

Senior Principal Scientist Requirements:
• 7+ years of post-doctoral and/or industry experience in drug discovery and development and ≥3 years of experience in safety risk assessment is a must

Requirements for both levels

• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field
• Strong collaboration, scientific leadership, and communication skills, with the ability to translate complex computational results into actionable insights for stakeholders with diverse backgrounds
• Expertise in computational toxicology, AI/ML modeling, and multi-omics (TGx) data integration
• Experience with in silico safety, liability prediction, and mechanistic modeling
• Familiar with toxicology related data curation, and interpretation, and knowledge of GLP toxicology and regulatory guidance will be a favorable plus

Eligibility Requirements
• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older
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Compensation Data

The base salary range for the Scientist II position is $140,000 to $222,000.

The base salary range for the Scienitst III position is $170,0000 to $269,000.

The position may be eligible for a role specific discretionary bonus, relocation, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, and qualifications, and other factors permitted by law. For an overview of our benefits please click here .

Our Company

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at www.boehringer-ingelheim.com.

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com