Senior Principal Scientist, AI-Powered Computational Safety

Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield (CT); On-site; USD 141,000 - 211,000; Full time

Benefits offered by this job

Discretionary bonus

Relocation assistance

Total Rewards program

Job summary

Boehringer Ingelheim Pharmaceuticals, Inc. seeks a Senior Principal/Principal Scientist in Computational Safety to lead in silico safety efforts across drug discovery and development.

You will leverage multi-omics data, AI/ML, and systems toxicology to identify safety liabilities and guide risk-based decisions. You will develop integrated computational safety strategies, including foundation models, AoP development, and cross-disciplinary collaboration with toxicology, discovery, and IT to

Qualifications

• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field
• Strong collaboration, scientific leadership, and communication skills
• Expertise in computational toxicology, AI/ML modeling, and multi-omics data integration
• Experience with in silico safety, liability prediction, and mechanistic modeling
• Familiar with toxicology data curation and GLP regulatory guidance is a plus

Responsibilities

• Lead and/or generate in silico target safety assessment strategy development
• Deliver integrated computational safety packages to support program decisions
• Advance AI/ML and multi-omics–based models, including foundation models, for safety and liability prediction
• Drive AI-enabled AoP development for mechanistic risk assessment
• Identify and communicate on target and off-target safety risks
• Collaborate with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams
• Translate complex computational insights to stakeholders across disciplines

Skills

Scientific leadership

Communication

AI/ML modeling

Multi-omics

In silico safety

Education

Ph.D. in Computational Toxicology or related field

Job description

Boehringer Ingelheim Pharmaceuticals, Inc. seeks a Senior Principal/Principal Scientist in Computational Safety to lead in silico safety efforts across drug discovery and development.

You will leverage multi-omics data, AI/ML, and systems toxicology to identify safety liabilities and guide risk-based decisions. You will develop integrated computational safety strategies, including foundation models, AoP development, and cross-disciplinary collaboration with toxicology, discovery, and IT to