Senior Principal Scientist - AI-Driven Computational Safety

Boehringer Ingelheim GmbH; Ridgefield (CT); On-site; USD 140,000 - 269,000; Full time

Job summary

Boehringer Ingelheim is seeking a Senior Principal/Principal Scientist in Computational Safety to lead in silico safety assessments across drug discovery. You will develop AI/ML, multi-omics, and AoP-based models, and translate computational insights into actionable strategies for risk-based decisions.

You will collaborate with toxicology, discovery, clinical safety, and IT teams to advance mechanistic safety and improve pipeline outcomes.

Qualifications

• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field.
• Strong collaboration, scientific leadership, and communication skills.
• Expertise in computational toxicology, AI/ML modeling, and multi-omics (TGx) data integration.
• Experience with in silico safety, liability prediction, and mechanistic modeling.
• Familiar with toxicology data curation, and interpretation, and knowledge of GLP toxicology and regulatory guidance will be a favorable plus

Responsibilities

• Lead and/or generate in silico target safety assessment strategy development.
• Develop and deliver integrated computational safety packages to support program and portfolio decisions.
• Advance AI/ML and multi omics-based models, including foundation models, for safety and liability prediction.
• Drive AI enabled Adverse Outcome Pathway (AoP) development to support mechanistic risk assessment.
• Proactively identify and communicate on target and off target safety risks.
• Collaborate closely with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams.
• Serve as a bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.

Skills

Computational toxicology

AI/ML modeling

Multi-omics data integration

Scientific leadership

Communication skills

Education

Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field

Job description

Boehringer Ingelheim is seeking a Senior Principal/Principal Scientist in Computational Safety to lead in silico safety assessments across drug discovery. You will develop AI/ML, multi-omics, and AoP-based models, and translate computational insights into actionable strategies for risk-based decisions.

You will collaborate with toxicology, discovery, clinical safety, and IT teams to advance mechanistic safety and improve pipeline outcomes.