Senior Principal Project Manager – cGMP Facility Upgrades

Lonza; Vacaville (CA); On-site; Confidential; Full time

Benefits offered by this job

Performance-related bonus

Medical, dental and vision insurance

401(k) matching plan

Life insurance

Short-term and long-term disability

Employee assistance programs

Paid Time Off

Job summary

Lonza Vacaville is seeking a Principal Project Manager for site-based capital and expense projects. You will lead end-to-end upgrades, tech transfers, and new construction, ensuring compliance with cGMP, safety, and schedule requirements across Engineering, MSAT, and Quality teams.

The role requires strong budgeting discipline, stakeholder management at senior levels, and collaboration with procurement to optimize external contracts. This position is fully site-based in Vacaville, California.

Qualifications

• Bachelor’s degree in Chemical or Mechanical Engineering.
• Proven expertise in end-to-end project execution.
• Strong executive accountability for strict budget management, accelerated delivery schedules, and enterprise milestone targets.
• Executive-level oversight of complex, highly regulated operating environments, ensuring compliance with local, federal, and EHS standards.
• Exceptional ability to align expectations, communicate risks, and drive strategic alignment with senior leadership, legal, procurement, and client teams.
• Advanced expertise in orchestrating internal resources and partnering with procurement to negotiate high-value contractor and supplier agreements.

Responsibilities

• Lead end-to-end delivery of complex cGMP facility modifications, tech transfers, and capital projects from design through commissioning and closeout.
• Own project performance by strictly managing budgets and meeting milestone schedules for manufacturing upgrades and new construction.
• Ensure all engineering, construction, and operational activities adhere to regulatory requirements.
• Communicate project objectives, risks, and milestone status with senior management, client teams, procurement, legal, and F&E leadership.
• Partner with procurement to develop, negotiate, and manage external contracts and internal resources to optimize project delivery.
• Proactively identify project risks, resolve cross-functional conflicts, and align stakeholder expectations to ensure successful outcomes.
• Continuously refine project management procedures and ensure full compliance with internal project governance standards.

Skills

End-to-end project execution

Education

Bachelor’s degree in Chemical or Mechanical Engineering

Job description

Lonza Vacaville is seeking a Principal Project Manager for site-based capital and expense projects. You will lead end-to-end upgrades, tech transfers, and new construction, ensuring compliance with cGMP, safety, and schedule requirements across Engineering, MSAT, and Quality teams.

The role requires strong budgeting discipline, stakeholder management at senior levels, and collaboration with procurement to optimize external contracts. This position is fully site-based in Vacaville, California.