End to End Project Lead

Lonza; Vacaville (CA); On-site; Confidential; Full time

Benefits offered by this job

Performance-related bonus

Medical, dental and vision insurance

401(k) matching plan

Life insurance

Short-term and long-term disability

Employee assistance programs

Paid Time Off

Job summary

Lonza in Vacaville, California, seeks an experienced End-to-End Project Lead to plan, manage, and deliver design, construction, commissioning, and validation of asset modifications for site capabilities. This on-site role owns cost, scope, and schedule while driving cross-functional collaboration to meet business goals.

The position emphasizes regulatory readiness, cGMP compliance, and leadership of project teams, with relocation support for eligible candidates.

Qualifications

• Bachelor’s degree in Life Science, Engineering or Business Management required; Master’s degree preferred.
• 10+ years of experience in manufacturing/operations within pharma/biopharma or a similar regulated industry.
• Data-driven decision maker with strong problem-solving skills and knowledge of Lean/Six Sigma and cGMP.
• Proven experience in operational management and project leadership, with exposure to cross-functional teams.

Responsibilities

• Strategic Project Execution: Define scope and goals with stakeholders and justify alignment with market strategy.
• Engineering Design & Delivery: Translate requirements into technical design inputs for cost and timeline targets.
• PM Framework & Governance: Establish contractual frameworks and manage scope changes with Engineering leadership.
• Operational Excellence: Integrate downtime into master schedules and drive cross-functional validation.
• Leadership & Development: Build high-performing project teams and provide mentorship.
• Communication & Mediation: Facilitate information flow between Global Engineering and steering committees.
• Regulatory & Compliance: Lead readiness and mitigation plans for cGMP compliance and regulatory approval.

Skills

Project management

Strategic thinking

Leadership

Cross-functional collaboration

Regulatory/compliance

Education

Bachelor’s degree in Life Science, Engineering or Business Management

Master’s degree preferred

Tools

PMP Certification

Job description

Location: Vacaville, California

Relocation assistance is available for eligible candidates and their families, if needed.

This is a fully site‑based role. Working together in person supports close, real‑time collaboration and the technical precision needed to manufacture medicines to the highest quality and safety standards.

Reporting to the E2E Program Lead, the End-to-End Project Lead for 11*12k / 8*25k is responsible for planning, managing and delivering the design, construction, commissioning and validation of the existing asset modifications in order to build product-agnostic capabilities for the Vacaville site, ensuring all tech transfers and overall large, complex projects pertaining to the respective asset. The Asset E2E lead has the ownership of the cost, scope and schedule of the projects to achieve their business goals. In line with their strategic, technical and project management responsibilities, the E2E Lead leads all the project functions.

What you will get

The full-time base annual salary for this position is expected to range between $181,500 to $302,000. In addition, below you will find a comprehensive summary of the benefits package we offer:

• Performance-related bonus
• Medical, dental and vision insurance
• 401(k) matching plan
• Life insurance, as well as short-term and long-term disability insurance
• Employee assistance programs
• Paid Time Off

What you will do

• Strategic Project Execution: Define scope and goals with stakeholders, ensuring projects align with market strategy and economic justification.
• Engineering Design & Delivery: Translate requirements into technical design inputs to meet cost, timeline, and functionality targets.
• PM Framework & Governance: Partner with sponsors to establish contractual frameworks and manage scope changes with Engineering leadership.
• Operational Excellence: Integrate project downtime into master schedules and drive cross-functional validation across CAPEX and procurement.
• Leadership & Development: Build high-performing project teams, offering mentorship and feedback to ensure delivery excellence.
• Communication & Mediation: Facilitate information flow between Global Engineering and steering committees, mediating technical or logistical hurdles.
• Regulatory & Compliance: Lead operational readiness and mitigation plans to ensure cGMP compliance and successful regulatory approval.

What we are looking for

• Bachelor’s degree in Life Science, Engineering or Business Management. Master’s degree preferred.
• Demonstrated success in operational management, PMP Project Manager Certification, 6S and Lean Manufacturing, Lean Six Sigma green belt or black belt is preferred.
• 10+ years of experience in Manufacturing /operations role within the pharmaceutical, biopharmaceutical, or a similar regulated industry.
• Data driven decision maker and problem solver, with strong problem-solving skills.
• Understanding of operational excellence, including continuous improvement methodologies (e.g. Lean, Six Sigma, etc.)
• Strong understanding of and proven experience with cGMP requirements for biologics manufacturing.

About Lonza

At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone’s ideas, big or small, have the potential to improve millions of lives, and that’s the kind of work we want you to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table.

At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law.