Senior Principal/ Principal Scientist, Computational Safety

BioCT Innovation Commons; Ridgefield, Northern (CT, KY); Hybrid; USD 140,000 - 269,000; Full time

Job summary

Boehringer Ingelheim is seeking a Senior Principal/Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. The role leverages multi-omics data, systems toxicology, and AI/ML to identify liabilities and support mechanistic understanding while guiding risk-based decisions.

The incumbent will develop integrated computational safety strategies, including foundation-model based on multiple omics data, AoP

Qualifications

• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field.
• Strong collaboration, scientific leadership, and communication skills.
• Expertise in computational toxicology, AI/ML modeling, and multi-omics data integration.
• Experience with in silico safety, liability prediction, and mechanistic modeling.

Responsibilities

• Lead and/or generate in silico target safety assessment strategy development.
• Develop and deliver integrated computational safety packages to support program and portfolio decisions.
• Advance AI/ML and multi-omics–based models, including foundation models, for safety and liability prediction.
• Drive AI-enabled Adverse Outcome Pathway development to support mechanistic risk assessment.
• Proactively identify and communicate on target and off-target safety risks.
• Collaborate with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams.
• Bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.

Skills

AI/ML modeling

Multi-omics data integration

Collaboration & leadership

Communication skills

In silico safety

Education

Ph.D. in Computational Toxicology/Computational Biology/Bioinformatics

Job description

Description

We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to proactively identify safety liabilities, support mechanistic understanding, improve quality target identification, and facilitate risk based decision making.
The Senior Principal Scientist/ Principal will play a key role in developing and delivering integrated computational safety strategies, including AI enabled foundation model based on multiple omics data, Adverse Outcome Pathways, off-target identification, and predictive liability models. Working closely with toxicologists, discovery scientists, clinical safety, bioinformatics, data science, and IT partners, this position will translate complex computational insights into clear, actionable recommendations that improve pipeline quality and reduce late stage attrition.
As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• Lead and/or generate in silico target safety assessment strategy development
• Develop and deliver integrated computational safety packages to support program and portfolio decisions
• Advance AI/ML and multi omics–based models, including foundation models, for safety and liability prediction
• Drive AI enabled Adverse Outcome Pathway (AoP) development to support mechanistic risk assessment
• Proactively identify and communicate on target and off target safety risks
• Collaborate closely with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams
• Serve as a bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.

Requirements

Principal Scientist Requirements:

• 6+ years of post-doctoral and/or industry experience in drug discovery and development and ≤1 years of experience in safety risk assessment is a must

Senior Principal Scientist Requirements:

• 7+ years of post-doctoral and/or industry experience in drug discovery and development and ≤3 years of experience in safety risk assessment is a must

Requirements for both levels

• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field
• Strong collaboration, scientific leadership, and communication skills, with the ability to translate complex computational results into actionable insights for stakeholders with diverse backgrounds
• Expertise in computational toxicology, AI/ML modeling, and multi-omics (TGx) data integration
• Experience with in silico safety, liability prediction, and mechanistic modeling
• Familiar with toxicology related data curation, and interpretation, and knowledge of GLP toxicology and regulatory guidance will be a favorable plus

Eligibility Requirements

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older

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Compensation Data

The base salary range for the Principal position is $140,000 to $222,000.

The base salary range for the Sr. Principal position is $170,0000 to $269,000.