Senior Principal AI Platform Engineer: BYO Agent Framework

Vertex Pharmaceuticals Inc (US); Boston (MA); On-site; USD 188,000 - 282,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

Generous PTO and holidays

401(k) plan with match

Commuting and relocation support

Job summary

Vertex Pharmaceuticals is seeking a Sr. Principal AI Engineer to design, build, and optimize a shared Agentic AI Platform powering AI-enabled products and workflows across the enterprise. You will enable build/bring-your-own-agents capabilities and establish reusable frameworks, guarding standards and governance.

The role combines strong software engineering with applied AI expertise, operating across rapid experimentation and rigorous production engineering to accelerate AI adoption at Vertex.

Qualifications

• Bachelor’s degree in Computer Science, Software Engineering, Machine Learning, Data Engineering, or a related field; advanced degree preferred.
• Significant industry experience in software engineering, machine learning engineering, or AI platform development, including senior or principal-level roles.
• Proven track record delivering production-scale AI or ML platforms.
• Strong experience building distributed systems, APIs, microservices, and cloud-native apps.
• Experience operationalizing machine learning, generative AI, or agent-based solutions in enterprise environments.
• Ability to design extensible platform capabilities for internal teams and ensure governance around AI tooling and agents.

Responsibilities

• Architect and develop shared AI/agentic platform services to support enterprise AI products and internal workflows.
• Design and implement a build/bring-your-own-agents capability for teams to create, register, integrate, deploy, and manage agents within the platform.
• Establish reusable frameworks, SDKs, templates, interfaces, and guardrails for onboarding custom agents.
• Define agent lifecycle capabilities including registration, configuration, testing, deployment, monitoring, versioning, and retirement.
• Build integrations with foundation models, model gateways, APIs, and enterprise tools; ensure scalable AI infrastructure.
• Design systems for prompt orchestration, workflow execution, tool use, memory patterns, and agent coordination.

Skills

AI platform architecture

Distributed systems

Cloud-native

CI/CD & DevOps

Agentic AI / multi-agent systems

Performance optimization

Education

Bachelor’s degree in CS or related field

Advanced degree preferred

Tools

APIs

Job description

Vertex Pharmaceuticals is seeking a Sr. Principal AI Engineer to design, build, and optimize a shared Agentic AI Platform powering AI-enabled products and workflows across the enterprise. You will enable build/bring-your-own-agents capabilities and establish reusable frameworks, guarding standards and governance.

The role combines strong software engineering with applied AI expertise, operating across rapid experimentation and rigorous production engineering to accelerate AI adoption at Vertex.