Senior Pharmacometric Lead - Clinical PK & DMPK

Summit Therapeutics; Palo Alto (CA); On-site; USD 174,000 - 204,000; Full time

Benefits offered by this job

Pay Transparency

Equal Opportunity Employer

Job summary

Summit Therapeutics Inc. in Palo Alto, CA, is seeking an Associate Director, Clinical Pharmacology & DMPK to lead pharmacometrics and data analysis for its oncology assets.

The role combines hands-on modeling with strategic input to support dose optimization, PK/PD analyses, and regulatory submissions. You will collaborate with cross-functional teams, oversee external vendors, and drive model-based decisions to inform development programs and help advance clinical studies for NSCLC and other

Qualifications

• Pharmacometric modeling and quantitative analysis in pharma/biotech settings.
• Hands-on modeling using NONMEM/PsN, R, and WinNonlin.
• Experience supporting dose selection, trial design, and regulatory submissions.

Responsibilities

• Serve as pharmacometrics SME on cross-functional teams and develop MIDD strategies.
• Design and run NCA, PopPK, PK/PD, MBMA, and exposure–response analyses with data processing and simulation.
• Develop quantitative models to support trial design and program decisions.
• Collaborate with Clinical Development, Biostatistics, Regulatory, and Data Management to ensure robust data collection and interpretation.
• Prepare analysis plans and regulatory submission sections, contributing to health authority responses.
• Oversee external pharmacometrics vendors and ensure quality of analyses.

Skills

Pharmacometric modeling

Hands-on data analysis

Education

Ph.D., Pharm.D., or equivalent

MS in pharmacometrics or related field

Tools

NONMEM/PsN

R

Phoenix WinNonlin

Job description

Summit Therapeutics Inc. in Palo Alto, CA, is seeking an Associate Director, Clinical Pharmacology & DMPK to lead pharmacometrics and data analysis for its oncology assets.

The role combines hands-on modeling with strategic input to support dose optimization, PK/PD analyses, and regulatory submissions. You will collaborate with cross-functional teams, oversee external vendors, and drive model-based decisions to inform development programs and help advance clinical studies for NSCLC and other