Senior P2P Enablement Lead — Hybrid & AI-Driven Platform

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 135,000 - 203,000; Full time

Job summary

Vertex is hiring a Senior Manager, P2P Process & Platform Enablement to lead and advance Procure-to-Pay execution enablement across requisitioning, approvals, catalogs, PO changes, receiving and supplier information management. You will partner with Procurement Operations, Finance/AP, IT/Digital and COE towers to deliver reliable outcomes and continuous improvement.

The role emphasizes change management, release readiness, supplier enablement, and data quality, leveraging AI and automation to

Qualifications

• 8+ years supporting and enabling Procure-to-Pay processes and platforms in a business, COE, or product ownership role.
• Strong understanding of end-to-end P2P execution including requisitioning, approvals, PO management, receiving, invoice processing, and matching.
• Hands-on experience defining requirements, UAT, enablement enhancements, and user training.
• Expert Change Agent with ability to plan, communicate, and execute platform releases with cross-functional teams.
• Extensive deployment of AI, RPA, OCR, and other technologies within P2P.

Responsibilities

• Lead P2P process and platform ownership, including requisitioning, approvals, catalogs, PO changes, receiving, invoice matching, and payment handoffs.
• Manage SIM onboarding, profiling, and workflows with operations and data stewards.
• Own enablement roadmap with enhancements, configuration changes, and defect remediation.
• Drive change, release readiness, testing, UAT, and go-live prep to avoid disruptions.
• Advance controls, compliance, and operational integrity across P2P workflows.
• Lead supplier enablement and data quality across P2P tools.
• Coordinate with Procurement Ops, IT/Digital, and other S2P teams for stable operations.
• Collaborate with Strategy, Governance, Analytics and Master Data teams to support KPIs.

Skills

8+ years P2P experience

End-to-end P2P understanding

Hands-on requirements definition

Change management & communication

AI, RPA, OCR in P2P

Tools

Coupa

SIM

Job description

Vertex is hiring a Senior Manager, P2P Process & Platform Enablement to lead and advance Procure-to-Pay execution enablement across requisitioning, approvals, catalogs, PO changes, receiving and supplier information management. You will partner with Procurement Operations, Finance/AP, IT/Digital and COE towers to deliver reliable outcomes and continuous improvement.

The role emphasizes change management, release readiness, supplier enablement, and data quality, leveraging AI and automation to