Senior Omics Scientist: Multi-Omics & AI for Immunology

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 109,000 - 175,000; Full time

Job summary

Johnson & Johnson’s Spring House, PA campus seeks a Senior Scientist to join the Population Analytics & Insights group (DDSAI) to advance drug target identification and evaluation for Immunology programs. Lead analysis of multi-omics and clinical datasets, applying NLP/ML to derive actionable targets and biomarkers.

You will collaborate across teams to translate computational insights into biological validation and contribute to drug discovery efforts in a fast-paced environment.

Qualifications

• Ph.D. in a quantitative Biology field is required.
• 2-3 years experience post PhD degree is required.
• Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level is required.
• Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines, are required.
• Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams are required.
• Experience with Immunology is preferred.
• Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis, is preferred.
• Experience with NLP, ML/AI, LLM to extract annotations from unstructured data is preferred.

Responsibilities

• Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.
• Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions.
• These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.
• Provide scientific technical expertise in modeling multimodal data (including genetic, perturbation and functional data) to predict qualities and liabilities associated with on- and off-target treatment effects.
• Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.
• Provide design and analysis consultation for questions of interest to our Immunology stakeholders and facilitate interactions between colleagues across the organization.
• Translate findings from computational analyses to support functional, biological and pharmacological validation.
• Work cooperatively with different teams in Data Sciences and Therapeutic Discovery teams to implement NLP or related approaches to annotate targets, biomarkers and networks to complement classifier construction.

Skills

Advanced Analytics

Data Science

Data Visualization

Machine Learning

Statistical Modeling

Biology Data Analysis

Collaboration

Programming

Education

Ph.D. in Quantitative Biology

Job description

Johnson & Johnson’s Spring House, PA campus seeks a Senior Scientist to join the Population Analytics & Insights group (DDSAI) to advance drug target identification and evaluation for Immunology programs. Lead analysis of multi-omics and clinical datasets, applying NLP/ML to derive actionable targets and biomarkers.

You will collaborate across teams to translate computational insights into biological validation and contribute to drug discovery efforts in a fast-paced environment.