Senior Scientist Omics - IMM

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 109,000 - 175,000; Full time

Job summary

Johnson & Johnson’s Spring House, PA campus seeks a Senior Scientist to join the Population Analytics & Insights group (DDSAI) to advance drug target identification and evaluation for Immunology programs. Lead analysis of multi-omics and clinical datasets, applying NLP/ML to derive actionable targets and biomarkers.

You will collaborate across teams to translate computational insights into biological validation and contribute to drug discovery efforts in a fast-paced environment.

Qualifications

• Ph.D. in a quantitative Biology field is required.
• 2-3 years experience post PhD degree is required.
• Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level is required.
• Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines, are required.
• Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams are required.
• Experience with Immunology is preferred.
• Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis, is preferred.
• Experience with NLP, ML/AI, LLM to extract annotations from unstructured data is preferred.

Responsibilities

• Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.
• Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions.
• These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.
• Provide scientific technical expertise in modeling multimodal data (including genetic, perturbation and functional data) to predict qualities and liabilities associated with on- and off-target treatment effects.
• Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.
• Provide design and analysis consultation for questions of interest to our Immunology stakeholders and facilitate interactions between colleagues across the organization.
• Translate findings from computational analyses to support functional, biological and pharmacological validation.
• Work cooperatively with different teams in Data Sciences and Therapeutic Discovery teams to implement NLP or related approaches to annotate targets, biomarkers and networks to complement classifier construction.

Skills

Advanced Analytics

Data Science

Data Visualization

Machine Learning

Statistical Modeling

Biology Data Analysis

Collaboration

Programming

Education

Ph.D. in Quantitative Biology

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Data Analytics & Computational Sciences

Job Sub Function

Data Science

Job Category

Scientific/Technology

All Job Posting Locations

Spring House, Pennsylvania, United States of America

Job Description

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine Johnson and Johnson Innovative Medicine (JJIM) is recruiting a Senior Scientist to work within the Population Analytics & Insights group (Data, Data Sciences and AI DDSAI organization) on drug target identification and evaluation to support alignment of priorities with the Immunology therapeutic area. The primary location for this position is at the Spring House, PA campus. The DDSAI organization develops innovative solutions using a variety of data sources across multiple different disease areas. We are looking for a highly motivated and self-driven individual who will creatively analyze large-scale clinical, genetic, omics and cell phenotype data to advance our drug discovery and development pipeline in R&D. At J&J, we strive to bring in the brightest minds in pursuit of developing effective and safe therapeutics for patients around the globe.

Role & responsibilities

• Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.
• Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions.
• These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.
• Provide scientific technical expertise in modeling multimodal data (including genetic, perturbation and functional data) to predict qualities and liabilities associated with on- and off-target treatment effects.
• Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.
• Provide design and analysis consultation for questions of interest to our Immunology stakeholders and facilitate interactions between colleagues across the organization.
• Translate findings from computational analyses to support functional, biological and pharmacological validation.
• Work cooperatively with different teams in Data Sciences and Therapeutic Discovery teams to implement NLP or related approaches to annotate targets, biomarkers and networks to complement classifier construction.

Job Qualifications

• A Ph.D. in a quantitative Biology field - Bioinformatics, Computational Biology, Systems Biology, Statistical Genetics, or related fields is required.
• 2-3 years experience post PhD degree is required.
• Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level is required.
• Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines, are required.
• Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams are required.
• Independent, self-motivated, innovative, and able to excel in a goal-oriented, multifaceted and fast-moving team environment are required.
• Experience with Immunology is preferred.
• Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis, is preferred.
• Expertise in perturbation data and analysis is preferred.
• Experience with advanced analytical approaches (NLP, ML/AI, LLM) to extracting relevant sources of annotation of cellular states, functions and localization from unstructured data is preferred.
• Experience with predictive models associated with evaluation of target engagement and druggability is preferred.
• Experience with drug discovery and development practices and project support in a large pharmaceutical setting are preferred.

Required Skills

• Advanced Analytics
• Business Intelligence (BI)
• Coaching
• Collaboration
• Critical Thinking
• Data Analysis
• Database Management
• Data Privacy Standards
• Data Reporting
• Data Savvy
• Data Science
• Data Visualization
• Econometric Models
• Process Improvements
• Technical Credibility
• Technologically Savvy
• Workflow Analysis

Preferred Skills

• Advanced Analytics
• Business Intelligence (BI)
• Coaching
• Collaboration
• Critical Thinking
• Data Analysis
• Database Management
• Data Privacy Standards
• Data Reporting
• Data Savvy
• Data Science
• Data Visualization
• Econometric Models
• Process Improvements
• Technical Credibility
• Technologically Savvy
• Workflow Analysis

Pay

The anticipated base pay range for this position is : $109,000.00 - $174,800.00

Additional Description for Pay Transparency

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

Equal Opportunity Employer

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource.