Senior Oligonucleotide Synthesis Scientist

Regeneron Pharmaceuticals, Inc; Town of Mount Pleasant (NY); On-site; USD 80,000 - 131,000; Full time

Job summary

Regeneron Genetic Medicines is seeking a Sr. Associate Scientist to join the RGM R&D Chemistry team focusing on oligomer and oligonucleotide synthesis, purification, and analytical characterization.

You will design and execute solid-phase workflows, prepare modified RNA-related materials, and generate data to guide platform research. The role requires a BS with 5 years experience (3 if MS) in solid-phase synthesis, with familiarity in automated synthesis platforms (e.g., MerMade, OligoSynt).

Qualifications

• BS in chemistry, biochemistry, chemical biology, biology, or related field; MS preferred.
• 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience.
• Hands-on experience with solid-phase organic synthesis, especially oligonucleotide or related polymer/biopolymer synthesis workflows.
• Familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers; purification and analytical methods like SEC, AEX, RP-HPLC or RP-IP-HPLC, LC-MS.

Responsibilities

• Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms; prepare reagents and set up cycles.
• Support synthesis of RNA-related constructs for discovery and platform development.
• Develop and troubleshoot synthetic workflows to improve yield, purity, and efficiency.
• Purify synthesized oligomers using chromatographic techniques (SEC, AEX, RP-HPLC, RP-IP-HPLC).
• Characterize purified materials with LC-MS, HPLC/UPLC, UV-Vis and orthogonal methods.
• Interpret results, summarize findings, and suggest next steps for design and advancement.
• Maintain accurate experimental records and support instrument maintenance and inventory.

Skills

Oligonucleotide synthesis

Solid-phase synthesis

Analytical characterization

Automated synthesis platforms

LC-MS

Education

BS in Chemistry

MS preferred

Tools

MerMade

OligoSynt

RP-HPLC

SEC

AEX

LC-MS

Job description

Regeneron Genetic Medicines is seeking a Sr. Associate Scientist to join the RGM R&D Chemistry team focusing on oligomer and oligonucleotide synthesis, purification, and analytical characterization.

You will design and execute solid-phase workflows, prepare modified RNA-related materials, and generate data to guide platform research. The role requires a BS with 5 years experience (3 if MS) in solid-phase synthesis, with familiarity in automated synthesis platforms (e.g., MerMade, OligoSynt).