Associate Scientist, Conjugation (Chemistry)

SanegeneBio Inc.; Boston (MA); On-site; USD 70,000 - 90,000; Full time

Job summary

SanegeneBio Inc. is seeking an Associate Scientist in Boston to support oligonucleotide synthesis and analytical activities for nucleic acid therapeutics. The role requires a Bachelor’s degree in a science-related field, proficiency in organic synthesis, and strong communication skills. Key responsibilities include operating synthesizers, conducting analytical testing with HPLC and LC-MS, and collaborating with multidisciplinary teams. Join a leading biotech company dedicated to advancing RNAi-powered medicines.

Qualifications

• Bachelor’s degree in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related field.
• Strong understanding of organic synthesis principles.
• Ability to analyze and solve technical problems independently.
• Proactive, well-organized, and capable of driving tasks and projects forward.
• Strong communication skills, including English proficiency and presentation abilities.
• Good teamwork skills and ability to work in multidisciplinary teams.

Responsibilities

• Perform oligonucleotide synthesis and preparation to support nucleic acid drug research.
• Operate oligonucleotide synthesizers to complete routine synthesis; optimize conditions and troubleshoot issues.
• Conduct analytical testing using HPLC, LC-MS, and related techniques.
• Collaborate with internal teams to support project needs.

Skills

Organic synthesis principles

Problem analysis and technical solving

Communication skills

Teamwork

Education

Bachelor’s degree in Organic Chemistry, Medicinal Chemistry, or related field

Tools

HPLC

LC-MS

Oligonucleotide synthesizers

Job description

Suzhou, China

Position Overview

SanegeneBio is a global, venture‑backed, clinical stage biotech company advancing best‑in‑class genetic medicines. We are 70+ employees with a single vision: unlocking the full potential of RNAi‑powered medicines for metabolic and autoimmune diseases. With our corporate headquarters and platform research center in the Boston area, as well as R&D and clinical operations in China, SanegeneBio is well‑positioned to develop innovative oligonucleotide therapeutics and change lives. Our LEAD™ siRNA delivery and chemistry platform enables systemic delivery to tissues and cell types of therapeutic relevance with a strong selectivity, tolerability, potency and duration of action profile. Our Core Values foster cross‑functional collaboration, continuous learning, scientific rigor, and an enduring spirit of optimism.

We are seeking an Associate Scientist, Conjugation (Chemistry) to join our team. This role will support oligonucleotide synthesis, conjugation, and analytical activities for nucleic acid therapeutics programs, collaborating with cross‑functional teams. This position provides an opportunity to develop hands‑on expertise in synthesis and analytical workflows while supporting project needs.

Key Responsibilities

• Perform oligonucleotide synthesis and preparation to support nucleic acid drug research.
• Operate oligonucleotide synthesizers (e.g., Dr. Oligo 48, Dr. Oligo 192, MerMade 12) to complete routine synthesis; optimize conditions and troubleshoot issues.
• Maintain and ensure proper use of synthesis equipment.
• Conduct analytical testing using HPLC, LC‑MS, and related techniques.
• Assist in updating and improving SOPs for oligonucleotide synthesis.
• Participate in purification and formulation preparation as needed.
• Collaborate with internal teams to support project needs.

Qualifications

• Bachelor’s degree in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related field.
• Strong understanding of organic synthesis principles.
• Ability to analyze and solve technical problems independently.
• Proactive, well‑organized, and capable of driving tasks and projects forward.
• Strong communication skills, including English proficiency and presentation abilities.
• Good teamwork skills and ability to work in multidisciplinary teams.