Senior mRNA Process Development Scientist

Avantor

Bridgewater (MA)

On-site

USD 108,000 - 173,000

Full time

3 days ago

Be an early applicant

Get more replies from employers

Send a job-specific resume in minutes.

Benefits offered by this job

Medical, dental, vision

401(k) with match

Paid holidays

Parental leave

Job summary

Avantor is seeking a Ph.D.-level scientist to design and implement end-to-end mRNA manufacturing processes, from DNA template generation to purified mRNA and formulation interface, in close collaboration with customers and internal teams.

The role requires 5+ years of industry experience in mRNA or related fields, with expertise in DOE/QbD, scale-up, analytical characterization, and data-driven problem solving. Join a global team driving life-changing science and patient outcomes.

Qualifications

Ph.D. in a related field is required.
Minimum 5+ years of relevant industry experience in mRNA, RNA, nucleic acid, biologics, or pharmaceutical process development.
Strong understanding of mRNA process development including DNA template generation, IVT, enzymatic processing, purification, and analytical characterization.
Hands-on experience with nucleic acid process development and scalable manufacturing processes.
Knowledge of DOE, QbD, process characterization, scale-up, CPP/CQA relationships.
Experience troubleshooting complex technical challenges and interpreting multidisciplinary data to develop data-driven solutions.
Excellent technical writing, presentation, project leadership, and cross-functional communication skills.

Responsibilities

Design, develop, and optimize end-to-end mRNA manufacturing processes.
Develop scalable workflows to improve yield, purity, quality, process robustness, and manufacturability.
Apply DOE, QbD, risk assessment, and statistical tools to build process understanding.
Collaborate with Analytical Development to characterize mRNA identity, integrity, purity, potency-related attributes, and process impurities.
Troubleshoot process and product-quality challenges using scientific and data-driven approaches.
Author technical reports, development summaries, risk assessments, SOPs, study protocols, and regulatory-support documentation.
Evaluate and demonstrate emerging technologies including synthetic DNA, novel purification approaches, automation, process intensification, and continuous manufacturing concepts.