Senior Molecular Technologist (Molecular Technologist III)

SeQure DX; Waltham (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

Equity option(s)

Generous time off

Job summary

MaxCyte seeks a Senior Molecular Technologist to join our Laboratory Operations team in Waltham, MA. You will perform novel NGS-based assays to assess on- and off-target edits for cell and gene therapy applications, providing hands-on leadership and technical troubleshooting.

The ideal candidate has 5+ years in a regulated molecular lab, experience with automated NGS workflows, and strong documentation skills. On-site, full-time role with opportunities for growth.

Qualifications

• Bachelor’s degree in clinical laboratory science, medical technology, molecular biology, or related field.
• 5+ years of relevant molecular lab experience in regulated environments (GLP/GMP/ISO).
• Experience with automated NGS workflows and laboratory documentation.
• Ability to troubleshoot complex molecular workflows and drive process improvements.
• Excellent written and verbal communication skills.

Responsibilities

• Perform complex molecular biology and NGS workflows: sample prep, nucleic acid processing, PCR, library prep, QC, sequencing.
• Operate and maintain automated platforms and sequencing instruments; ensure quality and turnaround times.
• Lead or troubleshoot assay failures, equipment issues, and automation errors.
• Support validation, technology transfer, and documentation; assist with SOPs and training.
• Manage multiple concurrent workflows with accuracy and documentation quality.

Skills

Molecular Biology

NGS Workflows

Regulated Lab

Troubleshooting

Education

Bachelor’s degree in related field

ASCP certification (preferred)

Tools

NGS Sequencers

Automated Liquid Handlers

Pipettes & Lab Equipment

Job description

MaxCyte SeQure platform is applying state of the art genomics technologies for CRISPR gene editor target profiling to advance discovery, clinical development, and diagnostic solutions. Our technologies provide the foundation needed to ensure that these life-saving therapies will be both safe and effective. This is an excellent opportunity to engage with established leaders in the field and become part of a dynamic team with substantial opportunities for growth and career development. MaxCyte offers a competitive compensation and benefits package and is an Equal Opportunity Employer.

We are seeking a Senior Molecular Technologist (Molecular Technologist III) to join our Laboratory Operations team to perform novel NGS based assays for the assessment of on- and off-target edits generated by gene editing technologies for cell and gene therapy applications. The ideal candidate will have extensive experience performing high-complexity molecular testing in a regulated laboratory environment, including automated NGS workflows, sequencing, quality control, equipment management, and technical troubleshooting. This individual will serve as a technical resource within Laboratory Operations, support the implementation and transfer of new assays, train junior personnel, and drive continuous improvement initiatives while remaining primarily hands-on at the bench.

Job Responsibilities

• Perform complex molecular biology and NGS workflows, including sample preparation, nucleic acid processing, PCR, library preparation, library purification, quality control, sequencing, and other downstream processing activities.
• Execute testing in accordance with approved Standard Operating Procedures, study-specific instructions, development protocols.
• Operate and maintain automated liquid handling platforms, NGS sequencers, and other molecular laboratory equipment, including pipettes, thermocyclers, centrifuges, fluorometers, and fragment analysis instruments.
• Lead or troubleshoot assay failures, equipment malfunctions, automation errors, and unexpected quality control results.
• Support assay, instrument, and automation validation activities, including equipment qualification, technology transfer, verification, and implementation.
• Manage multiple concurrent workflows while maintaining accuracy, documentation quality, and turnaround time commitments.
• Lead or substantially contribute to investigations of deviations, nonconformances, incidents, assay failures, and other quality events, including root cause analysis and corrective and preventive actions.
• Author, review, revise, and implement SOPs, work instructions, forms, training materials, validation documents, and other controlled quality records.
• Support laboratory inventory management, reagent qualification, vendor evaluation, material forecasting, and implementation of alternative supplies or vendors.

Requirements

• Bachelor’s degree in clinical laboratory science, medical technology, molecular biology, biochemistry, genetics, chemical or biological sciences, or a related discipline.
• 5+ years of relevant molecular laboratory experience, including experience in a regulated, clinical, GLP, GMP, ISO or similarly controlled laboratory environment.
• Demonstrated experience with automated NGS workflows, laboratory documentation, and quality systems in a regulated environment.
• Demonstrated ability to independently troubleshoot complex molecular workflows and drive laboratory process improvements. Demonstrated ability to manage multiple laboratory activities while maintaining accuracy, quality, and turnaround-time commitments.
• Excellent written and verbal communication skills.

Preferred Qualifications

• Experience with CRISPR gene editing, off-target analysis, or cell and gene therapy applications.
• Experience with hybrid capture, targeted enrichment, high-throughput sequencing, or complex multiplexed library preparation.
• Experience with amplicon-based sequencing, targeted amplicon panel workflows, or similar targeted NGS applications, including library preparation, amplification, pooling, quality control, and sequencing.
• Master’s degree in molecular biology, genomics, bioinformatics, biotechnology, or a related scientific discipline or ASCP certification in molecular biology or another relevant laboratory certification.

Work Environment & Logistics

• Full-time, exempt position
• 100% on-site in Waltham, Massachusetts
• Standard work schedule Monday through Friday
• No travel required

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status