Senior Molecular Pharmacology Lead – Drug Discovery

BioSpace; Indianapolis (IN); On-site; USD 149,000 - 257,000; Full time

Job summary

Lilly in Indianapolis, IN seeks experienced molecular pharmacology experts to optimize lead molecules and drive IND-ready candidates across oncology, immunology, and metabolic areas. The role demands deep scientific knowledge, leadership, and the ability to advance multiple programs while mentoring teams and collaborating across sites.

Onsite work with up to 2 lab days per week; strong background in GPCR signaling, radioligand binding, and imaging-based assays is essential, along with a growth

Qualifications

• Deep expertise in molecular pharmacology assay development and radioligand binding.
• Track record advancing discovery programs with drug hunter experience.
• Strong background in biochemistry, biophysics, and cell biology to guide optimization.
• Experience leading scientists and cross-disciplinary teams.
• Team player with rigorous scientific approach and growth mindset.

Responsibilities

• Design, develop, and execute pharmacology assays to support drug discovery programs.
• Characterize receptor pharmacology, affinity, selectivity, and functional activity.
• Lead cross-functional initiatives and provide scientific leadership across programs.
• Mentor diverse scientific talent and champion open, evidence-based decisions.
• Incorporate state-of-the-art methods and AI/ML into workflows.

Skills

Molecular pharmacology

Radioligand binding

GPCR signaling

Biochemistry

Cell biology

Team leadership

AI/ML in science

Education

PhD in Biochemistry/Biology/Biophysics/Molecular Biology/Pharmacology

Bachelor's degree with 10+ years equivalent experience

Tools

Confocal microscopy

High-content screening

FRET

Radioligand binding equipment

Job description

Lilly in Indianapolis, IN seeks experienced molecular pharmacology experts to optimize lead molecules and drive IND-ready candidates across oncology, immunology, and metabolic areas. The role demands deep scientific knowledge, leadership, and the ability to advance multiple programs while mentoring teams and collaborating across sites.

Onsite work with up to 2 lab days per week; strong background in GPCR signaling, radioligand binding, and imaging-based assays is essential, along with a growth