Senior Molecular Pharmacology Advisor: Lead Assay Design

BioSpace

Indianapolis (IN)

On-site

USD 126,000 - 205,000

Full time

45 hours ago

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Job summary

Lilly, headquartered in Indianapolis, Indiana, seeks a Advisor/Sr Advisor in Molecular Pharmacology to lead advanced assay design and data interpretation for GPCR programs. You will design and optimize screening cascades, study ligand-receptor interactions, and guide mechanistic investigations to inform candidate selection.

This role requires PhD or equivalent, independent thinking, and mentoring junior scientists.

Qualifications

PhD or equivalent in a relevant field.
Experience with GPCR pharmacology principles and data analysis.

Responsibilities

Design and implement screening cascade assays to drive SAR and compound optimization, leveraging pharmacology principles including receptor affinity, selectivity, and functional activity assessment.
Develop and execute assays that characterize ligand-receptor interactions, including radioligand binding, kinetic profiling, and functional assays.
Design imaging-based assays using confocal microscopy and HCS to investigate GPCR internalization, trafficking, and subcellular localization.
Independently investigate mechanistic behavior of molecules to inform compound optimization and target product profiles.
Represent Molecular Pharmacology on cross-functional project teams and provide expert guidance on pharmacology strategy.
Define hypotheses, success criteria, and timelines grounded in pharmacology principles.
Anticipate challenges and troubleshoot complex assay systems to ensure reliable data.
Maintain data quality and integrate cross-functional data to support go/no-go decisions.