Senior MES Engineer (Pharma)

ManpowerGroup Global, Inc.; Durham (NC); Hybrid; USD 83,000 - 96,000; Full time

Job summary

ManpowerGroup Global, Inc. in Durham, NC is seeking a Senior MES Engineer (Pharma) to support and optimize Manufacturing Execution Systems in regulated pharmaceutical manufacturing.

This contract‑to‑hire role focuses on maintaining PMX/Plex/FactoryTalk PharmaSuite MES, ensuring GMP/CSV compliance, and collaborating with engineering, IT, and quality teams. The position is a hybrid onsite arrangement with 4 days on site per week and offers a competitive hourly rate.

Qualifications

• 5+ years of MES experience in pharmaceutical manufacturing.
• Experience with Recipe Authoring for parenteral products.
• Hands-on PMX/Plex/FactoryTalk PharmaSuite in pharma settings or similar MES platforms.
• Familiarity with GAMP 5, 21 CFR Part 11, Annex 11.
• Bachelor’s degree in Engineering, Computer Science, IT, or equivalent.

Responsibilities

• Support and maintain PMX or Plex or FactoryTalk PharmaSuiteMES systems in GMP environments.
• Troubleshoot MES issues and act as Tier 2 escalation for production support.
• Assist with MES deployments, upgrades, and enhancements across sites.
• Develop, configure, and support EBRs and MBRs.
• Collaborate with engineering, manufacturing, IT, and quality teams to deliver compliant MES solutions.
• Maintain validation documentation throughout the system lifecycle (CSV).
• Contribute to MES standardization and replication initiatives.

Skills

MES support

GxP compliance

CSV validation

Regulatory knowledge

GMP familiarity

Education

Bachelor's in Engineering or IT

Tools

PMX

Plex

FactoryTalk PharmaSuite

Job description

We are looking for a talented SeniorMES Engineer (Pharma) to support and enhance Manufacturing Execution Systems used in regulated pharmaceutical manufacturing environments.

We are a global life sciences manufacturing organization focused on modernizing and expanding paperless manufacturing operations through enterprise MES platforms.

Role Basics

• Work Location: Hybrid onsite in Durham, NC (4 days per week)
• Employment Type: Contract-to-Hire
• Rate Range: $60–$70/hr W2

This role is NOT eligible for visa sponsorship or C2C

Job Duties

• Support and maintain PMX or Plex or FactoryTalk PharmaSuiteMES systems in GMP manufacturing operations
• Troubleshoot MES issues and act as a Tier 2 escalation point for production support
• Assist with MES deployments, upgrades, and functional enhancements across manufacturing sites
• Develop, configure, and support Electronic Batch Records (EBRs) and Master Batch Records (MBRs)
• Partner with engineering, manufacturing, IT, and quality teams to deliver compliant MES solutions
• Maintain validation documentation throughout the system lifecycle (CSV)
• Contribute to MES standardization and site‑to‑site replication initiatives

Ideal Background

• 5+ years of experience supporting Manufacturing Execution Systems (MES) within pharmaceuticalmanufacturing industry.
• Experience with Recipe Authoring for PFS (prefilled syringe) or similar Parenteral pharmaceuticals
• Hands‑on experience with PMX or Plex or FactoryTalk PharmaSuite in a pharmaceutical manufacturing environment (or other MES platforms such as: Siemens Opcenter, SAP Digital Manufacturing, NoMuda VisualFactory, Infor MES,Tulip Platform, iBase-t Solumina MES, Oracle Cloud Manufacturing, Dassault Systems DELMIA Apriso, DELMIAWORKS, HYDRA X, GE Vernova Proficy Smart Factory, L2L (Leading2Lean), Werum PAS‑X MES Suite by Korber Pharma, iTAC.MOM.Suite by iTAC Software, ProManage, TrakSYS by Parsec, 42Q, AVEVA Manufacturing Execution System, Trackwise by Honeywell, Honeywell Forge Operations Management, PINpoint MES, Emerson Syncade,MasterControl Manufacturing Excellence, Aegis Software FactoryLogix, Epicor Advanced MES, Sepasoft MES, ABB Ability Manufacturing Operations Management Suite, Tempo Manufacturing Cloud, Aptean Process Manufacturing OEE, Accevo MES, DeltaV Manufacturing Execution System by Emerson, AspenONE MES, Nexplant MESplus, Cantier MES,or Vimachem Pharma MES)
• Familiarity with GAMP 5, 21 CFR Part 11, and Annex 11
• Working knowledge of GMP, CSV, and regulated systems
• Bachelor’s degree in Engineering, Computer Science, IT, or equivalent experience

Why Us

• Contract‑to‑hire opportunity with long‑term career potential
• Hands‑on role supporting critical pharmaceutical manufacturing systems
• Exposure to enterprise MES modernization and PharmaSuite transformation initiatives
• Collaborative, cross‑functional environment with engineering, IT, and quality teams
• Competitive hourly rate and on‑call rotation compensation

We are recognized consistently for our diversity - as a best place to work for Women, Inclusion, Equality and Disability and in 2022 ManpowerGroup was named one of the World's Most Ethical Companies for the 13th year - all confirming our position as the brand of choice for in-demand talent.