Senior MES Engineer – Pharma, Hybrid, Contract-to-Hire

ManpowerGroup Global, Inc.; Durham (NC); Hybrid; USD 83,000 - 96,000; Full time

Job summary

ManpowerGroup Global, Inc. in Durham, NC is seeking a Senior MES Engineer (Pharma) to support and optimize Manufacturing Execution Systems in regulated pharmaceutical manufacturing.

This contract‑to‑hire role focuses on maintaining PMX/Plex/FactoryTalk PharmaSuite MES, ensuring GMP/CSV compliance, and collaborating with engineering, IT, and quality teams. The position is a hybrid onsite arrangement with 4 days on site per week and offers a competitive hourly rate.

Qualifications

• 5+ years of MES experience in pharmaceutical manufacturing.
• Experience with Recipe Authoring for parenteral products.
• Hands-on PMX/Plex/FactoryTalk PharmaSuite in pharma settings or similar MES platforms.
• Familiarity with GAMP 5, 21 CFR Part 11, Annex 11.
• Bachelor’s degree in Engineering, Computer Science, IT, or equivalent.

Responsibilities

• Support and maintain PMX or Plex or FactoryTalk PharmaSuiteMES systems in GMP environments.
• Troubleshoot MES issues and act as Tier 2 escalation for production support.
• Assist with MES deployments, upgrades, and enhancements across sites.
• Develop, configure, and support EBRs and MBRs.
• Collaborate with engineering, manufacturing, IT, and quality teams to deliver compliant MES solutions.
• Maintain validation documentation throughout the system lifecycle (CSV).
• Contribute to MES standardization and replication initiatives.

Skills

MES support

GxP compliance

CSV validation

Regulatory knowledge

GMP familiarity

Education

Bachelor's in Engineering or IT

Tools

PMX

Plex

FactoryTalk PharmaSuite

Job description

ManpowerGroup Global, Inc. in Durham, NC is seeking a Senior MES Engineer (Pharma) to support and optimize Manufacturing Execution Systems in regulated pharmaceutical manufacturing.

This contract‑to‑hire role focuses on maintaining PMX/Plex/FactoryTalk PharmaSuite MES, ensuring GMP/CSV compliance, and collaborating with engineering, IT, and quality teams. The position is a hybrid onsite arrangement with 4 days on site per week and offers a competitive hourly rate.