Senior Medical Director - Oncology

Barrington James; Massachusetts; On-site; USD 180,000 - 260,000; Full time

Job summary

Barrington James is seeking a strategic, senior physician-scientist to own late-stage oncology development programs end-to-end, from clinical strategy through regulatory submission. You will lead cross-functional teams and engage Health Authorities with confidence.

The role centers on late-stage (Phase 2/3) program leadership, with responsibilities to set direction, mentor juniors, and drive registration-enabling activities within a big biotech / big pharma environment in Massachusetts.

Qualifications

• MD required as core credential for the role (physician-scientist).
• Minimum 5+ years in industry clinical R&D within pharma/biotech.
• Experience leading or supporting Phase 1–3 studies, with emphasis on late-stage programs.

Responsibilities

• Own a Clinical Development Plan as the clinical lead for a program.
• Lead or support studies across the full Phase 1–3 continuum, focused on late-stage programs.
• Prepare for and present to Health Authorities (FDA/EMA).
• Coordinate resources and provide strategic direction across a program, including mentoring junior staff.
• Interpret translational/biomarker data to support development decisions.
• Mentor junior Medical Directors and help shape team culture.

Skills

Cross-functional leadership

Regulatory interactions

Clinical development strategy

Biomarker data interpretation

Education

MD degree

Job description

About the Role

This is a strategic, senior-level physician-scientist role, owning late-stage oncology development programs end-to‑end — from clinical strategy through regulatory submission. The team needs someone who can set direction, lead cross‑functional teams, and engage Health Authorities with confidence not a pure study executor. Late‑stage (Phase 2/3) program leadership is the top priority for this opening.

What You'll Do

• Own a Clinical Development Plan (CDP) as the responsible clinical lead for a program — not just execute studies
• Lead or support studies across the full Phase 1–3 development continuum, with a focus on late‑stage programs
• Prepare for and present to Health Authorities (FDA/EMA)
• Coordinate resources and provide strategic direction across a program, including managing junior team members
• Interpret and apply translational/biomarker data to development decisions
• Mentor junior Medical Directors and help shape team culture

What You'll Bring

• MD required (Mandatory)
• Strong oncology expertise, ideally solid tumors; hematology a plus
• Minimum 5 years' industry clinical R&D experience at pharma/biotech
• Experience leading or supporting studies across the full Phase 1–3 continuum
• Demonstrated contribution to registration‑enabling activities and Health Authority interactions
• Ability to work across global, matrixed teams
• ICH‑GCP/FDA/EMA regulatory fluency
• End‑to‑end development experience in a big biotech / big pharma environment