Senior Mass Spectrometry Scientist - LC-MS & GMP

Actalent; Wilmington (NC); On-site; USD 63,000 - 77,000; Full time

Benefits offered by this job

Medical, dental & vision

401(k) Retirement Plan

Paid time off

Job summary

Actalent is seeking a Senior Scientist I, Mass Spectrometry, in Wilmington, NC. The role is fully onsite, with up to 5% domestic travel, and involves developing and validating analytical methods using HPLC, LC‑MS, and GC‑MS for complex small‑molecule applications.

The candidate will perform routine and non‑routine testing, interpret data, participate in audits, and ensure GMP documentation and compliance. Exceptional organization and communication skills are required.

Qualifications

• Bachelor's degree in Chemistry with 8+ years of relevant experience.
• Master's degree with 4+ years of relevant experience.
• PhD with 2+ years of relevant experience.
• At least 2 years of cGMP experience in a pharmaceutical or regulated environment.
• Mass‑spectrometry experience involving GC‑MS, LC‑MS, triple‑quadrupole, or QTOF systems.
• Experience performing quantitative or qualitative mass‑spectrometry work.
• Experience developing and implementing analytical methods or laboratory processes.
• Working knowledge of cGMP requirements.

Responsibilities

• Perform routine and non‑routine analytical testing in support of pharmaceutical development and manufacturing.
• Use HPLC, LC‑MS, and GC‑MS methods to evaluate residual solvents, nitrosamines, genotoxic impurities, and unknown impurities.
• Develop analytical methods using HPLC, LC‑MS, and GC‑MS technologies.
• Perform quantitative and qualitative mass‑spectrometry analysis using instrumentation such as triple‑quadrupole and QTOF systems.
• Develop and validate analytical methods, test procedures, protocols, and technical reports.
• Perform GMP review of laboratory solutions and chromatographic data.
• Apply the scientific and theoretical basis of analytical methods when designing experiments and interpreting results.
• Evaluate data for technical accuracy, scientific validity, and completeness.
• Troubleshoot analytical challenges and solve problems of varying complexity.
• Lead laboratory investigations and root‑cause analysis.
• Maintain current knowledge of applicable instrumentation, equipment, and scientific methodologies.
• Communicate technical information to clients and participate in client or regulatory audits.
• Support initiatives outside routine laboratory testing responsibilities.
• Safely handle potent compounds while following applicable laboratory and PPE requirements.
• Maintain a safe, clean, and organized laboratory environment.
• Complete required cGMP and company training within established timelines.
• Perform other duties as assigned.

Skills

mass spectrometry

analytical method development

analytical method validation

GMP

small molecule

HPLC

LC-MS

GC-MS

Education

Bachelor's in Chemistry

Master's degree

PhD

Tools

HPLC

LC-MS

GC-MS

QTOF

Triple-quadrupole

Job description

Actalent is seeking a Senior Scientist I, Mass Spectrometry, in Wilmington, NC. The role is fully onsite, with up to 5% domestic travel, and involves developing and validating analytical methods using HPLC, LC‑MS, and GC‑MS for complex small‑molecule applications.

The candidate will perform routine and non‑routine testing, interpret data, participate in audits, and ensure GMP documentation and compliance. Exceptional organization and communication skills are required.