Senior Manager NGS Bioinformatics

Mass General Brigham (Enterprise Services); Somerville (MA); On-site; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a dynamic leader in bioinformatics to oversee a talented team focused on next-generation sequencing (NGS). This role involves managing projects from inception to completion, ensuring compliance with regulatory standards, and fostering innovation within the team. The successful candidate will leverage their expertise in bioinformatics and leadership to drive strategic initiatives and deliver high-quality analyses. If you're passionate about advancing the field of bioinformatics and thrive in a collaborative environment, this opportunity is perfect for you.

Qualifications

• Ph.D. in Bioinformatics or related field with 8+ years of experience.
• Proven leadership in managing bioinformatics teams and projects.

Responsibilities

• Lead and manage a team of bioinformaticians, ensuring timely project delivery.
• Develop and implement pipelines for NGS data analysis.

Skills

Bioinformatics

NGS Data Analysis

Python

R

Perl

Leadership

Problem-Solving

Communication

Attention to Detail

Data Quality Control

Education

Ph.D. in Bioinformatics

Experience in Bioinformatics

Tools

GATK

SAMtools

BWA

Ensembl

COSMIC

SQL

NoSQL

Cloud Computing

Job description

The Opportunity

I. Leadership and Management:

• Lead and manage a team of bioinformaticians, providing mentorship and guidance.
• Work with senior leadership to establish goals and objectives, including defining work products and timelines.
• Participate in developing strategy and setting overall direction.
• Develop and implement strategic plans for the bioinformatics team.
• Ensure timely delivery of analyses and reports.
• Foster a collaborative and innovative team environment.
• Attract, retain, and develop high-quality staff.
• Establish and maintain a high-performance work environment.
• Address training and professional development needs of staff.

II. Project Management:

• Oversee bioinformatics aspects of NGS projects from start to finish.
• Coordinate with project managers, scientists, and stakeholders.
• Ensure projects are delivered on time, within scope, and budget.

III. Bioinformatics Analysis:

• Develop and implement pipelines, workflows, and tools for NGS data analysis.
• Perform data quality control, alignment, variant calling, and annotation.
• Interpret and present results to scientific and non-scientific audiences.
• Design and apply novel computational methods and algorithms.
• Analyze large molecular datasets, troubleshoot, and recommend solutions.
• Develop and validate new data analysis software tools.

IV. Research and Development:

• Stay current with advancements in NGS technologies and bioinformatics methods.
• Identify and integrate new tools and technologies.
• Lead research initiatives for novel bioinformatics approaches.

V. Collaboration and Communication:

• Work with multidisciplinary teams including scientists, clinicians, and healthcare professionals.
• Communicate complex concepts and results effectively.
• Prepare and present technical reports.

VI. Regulatory Compliance:

• Ensure analyses and reporting comply with standards (e.g., CLIA, CAP, FDA).
• Develop and maintain documentation and SOPs.
• Participate in audits and inspections.
• Perform other duties as assigned.

Qualifications

• Ph.D. in Bioinformatics, Computational Biology, Genomics, or related field.
• Minimum of 8 years experience in bioinformatics, focusing on NGS.
• Proven leadership in managing bioinformatics teams.
• Expertise in NGS data analysis and sequencing technologies.
• Proficiency in Python, R, Perl.
• Experience with tools/databases like GATK, SAMtools, BWA, Ensembl, COSMIC.
• Knowledge of clinical genomics regulations (CLIA, CAP, FDA).
• Strong problem-solving, attention to detail, and communication skills.

Skills, Abilities, and Competencies

• Experience in oncology or precision medicine.
• Familiarity with EHR systems and clinical data integration.
• Knowledge of cloud computing and high-performance environments.
• Scripting skills in Python or Perl.
• Experience developing software in CLIA environments (preferred).
• Proficiency in SQL, NoSQL, data engineering, and workflow platforms.
• Ability to manage large, heterogeneous datasets.
• Strong skills in Linux and high-performance computing clusters.
• Excellent interpersonal, communication, and problem-solving skills.
• Ability to work independently, prioritize, and adapt to changing priorities.
• Ability to collaborate in a fast-paced, challenging environment.
• Rapid learner and implementer of new technologies.
• Attention to detail and a track record of developing high-quality computational tools.

Additional Job Description

Mass General Brigham Incorporated is an Equal Opportunity Employer. We embrace diverse skills and perspectives. All qualified applicants will receive consideration without regard to race, color, religion, sex, age, gender identity, disability, sexual orientation, military service, genetic information, or other protected status. We provide reasonable accommodations for individuals with disabilities during the application and interview process, and for performing essential job functions.