Senior Manager NGS Bioinformatics

Mass General Brigham; Somerville (MA); Remote; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a Bioinformatics Team Leader to drive innovative research and development in next-generation sequencing (NGS). This role involves leading a talented team, managing complex projects, and developing cutting-edge bioinformatics tools. The ideal candidate will have extensive experience in bioinformatics, particularly in NGS data analysis, and possess strong leadership and communication skills. Join a diverse and inclusive organization dedicated to advancing patient care through groundbreaking research. This is a unique opportunity to make a significant impact in the field of healthcare and bioinformatics.

Qualifications

• 8+ years of experience in bioinformatics with a focus on NGS.
• Strong expertise in various sequencing technologies and data analysis.
• Proven experience in managing bioinformatics teams.

Responsibilities

• Lead a team of bioinformaticians, managing projects from inception to completion.
• Develop bioinformatics pipelines for NGS data analysis.
• Ensure compliance with regulatory standards in bioinformatics processes.

Skills

Bioinformatics

NGS Data Analysis

Python

R

Perl

Project Management

Communication Skills

Problem-Solving Skills

Education

Ph.D. in Bioinformatics, Computational Biology, or Genomics

Tools

GATK

SAMtools

BWA

Ensembl

COSMIC

MySQL

PostgreSQL

MongoDB

Airflow

Argo

Job description

Site: Mass General Brigham Incorporated

At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission - from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.

At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare - people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds - to apply.

Job Summary

The Opportunity

1. Leadership and Management: Lead and manage a team of bioinformaticians, providing mentorship and guidance. Work with senior leadership to establish goals and objectives including the definition of work products and timelines. Develop and implement strategic plans for the bioinformatics team. Ensure timely delivery of bioinformatics analyses and reports. Foster a collaborative and innovative team environment. Attract, retain and develop high-quality staff. Establish and maintain a work environment conducive to high performance. Address the training and professional development needs of the staff.
2. Project Management: Oversee the bioinformatics aspects of NGS projects from inception to completion. Coordinate with project managers, laboratory scientists, and other stakeholders. Ensure projects are delivered on time, within scope, and within budget.
3. Bioinformatics Analysis: Develop and implement bioinformatics pipelines and workflows and tools for NGS data analysis. Perform data quality control, alignment, variant calling, and annotation. Interpret and present results to scientific and non-scientific audiences. Design and apply novel computational methods/bioinformatics algorithms to aid in the analysis and interpretation of genetic data. Analyze large molecular datasets of tumor sequencing data to help critically review and analyze the results of specimen testing, working closely with faculty and staff to troubleshoot problems, recommend technology-based solutions, or determine computational strategies. Develop and validate new data analysis software tools to enhance the ability of faculty to interpret genetic data output.
4. Research and Development: Stay up-to-date with the latest advancements in NGS technologies and bioinformatics methods. Identify and integrate new tools and technologies to improve data analysis capabilities. Lead research initiatives to develop novel bioinformatics approaches.
5. Collaboration and Communication: Work closely with cross-functional teams including molecular scientists, geneticists, clinicians, pathologists, oncologists, and other clinical healthcare professionals. Communicate complex bioinformatics concepts and results to stakeholders. Prepare and present technical reports to all cross-functional teams.
6. Regulatory Compliance: Ensure all bioinformatics analyses and reporting comply with relevant regulatory standards (e.g., CLIA, CAP, FDA). Develop and maintain documentation and standard operating procedures (SOPs) for clinical bioinformatics processes. Participate in audits and inspections to ensure regulatory compliance. Perform all other duties as assigned.

Qualifications

1. Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field.
2. Minimum of 8 years of experience in bioinformatics, with a focus on NGS.
3. Proven experience in managing and leading bioinformatics teams.
4. Strong expertise in NGS data analysis, including experience with various sequencing technologies (e.g., Illumina, PacBio, Oxford Nanopore).
5. Proficiency in programming languages such as Python, R, and Perl.
6. Experience with bioinformatics tools and databases (e.g., GATK, SAMtools, BWA, Ensembl, COSMIC).
7. Knowledge of regulatory requirements for clinical genomics (e.g., CLIA, CAP, FDA).
8. Excellent problem-solving skills and attention to detail.
9. Strong communication and interpersonal skills.

Skills, Abilities and Competencies

1. Experience in oncology or precision medicine.
2. Familiarity with electronic health record (EHR) systems and clinical data integration.
3. Knowledge of cloud computing and high-performance computing environments.
4. Scripting using Python or Perl.
5. Prior experience developing software in a CLIA regulated environment is preferred.
6. SQL proficiency using MySQL and/or SqlServer, knowledge of NoSQL and other DBMS (e.g., PostgreSQL, MongoDB, Apache CouchDB) a plus.
7. Familiarity with data engineering and workflow management platforms (e.g., Airflow, Argo).
8. Ability to work with and manage large and heterogeneous data sets.
9. Excellent skills for working with the Linux operating system and high-performance computing clusters (HPCC), including the LSF queueing system to undertake genomic analyses from assembly of NGS reads through subsequent analyses.
10. Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts.
11. Excellent communication and effective problem-solving skills; and ability to interact with multidisciplinary staff in a fast-paced environment. The successful candidate should be able to work independently, prioritize and manage a variety of tasks, and shift priorities rapidly.
12. Ability to work in a highly collaborative and intellectually challenging environment.
13. Ability to rapidly assess, learn, and implement new technologies/services as new needs arise, as well as communicating use of those technologies.
14. Excellent attention to detail.
15. Proven track record of developing high-quality computational methods and tools in the form of scientific publications or through successful participation in hackathons, challenges, or open-source software projects.

Additional Job Details (if applicable)

Remote Type: Remote

Work Location: 399 Revolution Drive

Scheduled Weekly Hours: 40

Employee Type: Regular

Work Shift: Day (United States of America)

EEO Statement:

Mass General Brigham Incorporated is an Equal Opportunity Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.