Senior Manager, Analytical Sciences

Scorpion Therapeutics; San Diego (CA); Hybrid; USD 170,000 - 185,000; Full time

Benefits offered by this job

Hybrid work options

Job summary

Scorpion Therapeutics seeks a Lead analytical R&D scientist within ORIC's CMC group to provide analytical leadership for drug development programs in a fast-paced environment.

You will oversee method development, validation, and characterization, manage GMP-related activities, and author regulatory documents while collaborating with Regulatory, Quality, and Clinical supply teams to ensure data integrity and compliance.

Qualifications

• PhD in analytical chemistry or related field with 7–10+ years in pharma/biotech.
• Extensive hands-on experience with UHPLC, LC-MS, GC, and spectroscopic methods.
• Proven expertise in process chemistry, method development and validation for small molecules.
• Experience in late-stage development and regulatory submissions.
• Strong problem-solving, scientific curiosity, and independent working ability.

Responsibilities

• Oversee outsourced and in-house method development, validation, and characterization.
• Manage GMP manufacturing-related activities.
• Author regulatory documents.
• Collaborate with cross-functional teams including Regulatory, Quality, and Clinical supply.
• Ensure data integrity and regulatory compliance.

Skills

UHPLC

LC-MS

GC

Spectroscopic methods

Process chemistry

Method validation

Small molecules

Regulatory submissions

Problem-solving

Education

PhD in Analytical Chemistry

Tools

LC-MS instrumentation

UHPLC instruments

GC instruments

Job description

Role

Lead analytical R&D scientist in ORIC's CMC group, providing analytical leadership for drug development programs.

Responsibilities

• oversee outsourced and in-house method development, validation, and characterization;
• manage GMP manufacturing-related activities;
• author regulatory documents;
• collaborate with cross-functional teams including Regulatory, Quality, and Clinical supply;
• ensure data integrity and regulatory compliance.

Requirements

• Ph.D. in analytical chemistry or related field with 7-10+ years in pharma/biotech industry;
• extensive hands‑on experience with analytical technologies (UHPLC, LC-MS, GC, spectroscopic methods);
• proven expertise in process chemistry, method validation, and development for small molecules;
• experience in late-stage development and regulatory submissions;
• strong problem-solving, scientific curiosity, and independent working ability.

Preferred

• experience with Person-in-Plant oversight, working within commercial settings, and familiarity with toxicology and clinical development processes.

High-Value

focus on small molecules targeting cancer resistance mechanisms, including drug process development, stability, and NDA preparation.

Work Setup

• hybrid/remote options;
• location San Diego;
• salary $170K-$185K, commensurate with experience.