Senior Machine Learning Scientist II, Drug Discovery Analytics

Revolution Medicines; San Francisco (CA); On-site; USD 251,000 - 295,000; Full time

Job summary

Revolution Medicines seeks a Senior Machine Learning Scientist to accelerate drug discovery by building predictive models that transform complex biological and chemical data into actionable insights. You will operate at the interface of data science, chemistry, and biology, collaborating closely with experimental teams to guide research decisions.

Key tasks include developing models for activity, selectivity, ADME/Tox, and translational research, while leveraging deep learning, graph neural

Qualifications

• PhD in a quantitative field with strong ML focus.
• 6–10 years applying ML to scientific data.
• Proficiency with Python scientific stack.
• Experience with PyTorch, TensorFlow or scikit-learn.
• Experience handling noisy biological/chemical data.

Responsibilities

• Develop predictive models for drug discovery and compound activity.
• Design and implement ML models for ADME/Tox and target engagement.
• Apply deep learning, graph networks, and ensemble methods.
• Evaluate models and validate with appropriate strategies.
• Collaborate with data/ML engineers to deploy in pipelines.
• Analyze complex chemical, biology, and phenotypic data.
• Integrate diverse datasets including chemical, structural biology data.

Skills

PhD in ML/quant field

6–10 years ML in science

Python & NumPy/Pandas/SciPy

ML frameworks (PyTorch, TensorFlow)

Model dev, validation & eval

Data visualization & EDA

Handling noisy datasets

Education

PhD in ML/comp biology/comp chem/CS

Tools

RDKit

OpenEye

Job description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

• We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and artificial intelligence. This role will develop predictive models and analytical methods that transform complex biological and chemical datasets into actionable insights that guide research decisions.
• The Senior Machine Learning Scientist will work at the interface of data science, chemistry, and biology to support target discovery, compound optimization, and translational research. This position requires both strong machine learning expertise and the ability to collaborate effectively with experimental scientists to solve real-world scientific problems.
• The successful candidate will contribute to building a data-driven discovery ecosystem where data, analytics, and experimentation continuously inform and accelerate one another.

Key responsibilities

• Develop Predictive Models for Drug Discovery
• Independently Design and implement machine learning models to predict compound activity, selectivity, and developability.
• Identify and Develop predictive frameworks for ADME/Tox, target engagement, and phenotypic screening outcomes.
• Apply advanced modeling approaches including deep learning, graph neural networks, and ensemble methods.
• Evaluate model performance and apply appropriate validation strategies.
• Work with data engineers and ML engineers to integrate models into discovery pipelines.
• Analyze Complex Scientific Data.
• Perform exploratory data analysis on chemical, biological, and phenotypic datasets.
• Integrate heterogeneous datasets including:
• Chemical structure and screening data.
• Structural biology and molecular simulation outputs.
• Collaborate with Research Scientists.
• Partner with medicinal chemists to support compound design and lead optimization.
• Work with biologists to interpret experimental results and identify new target opportunities.
• Translate scientific questions into computational modeling strategies.

Required Skills, Experience and Education

• PhD in machine learning, computational biology, computational chemistry, computer science, statistics, or a related quantitative field.
• 6–10 years experience applying machine learning or advanced analytics to scientific datasets.
• Python and scientific computing libraries (NumPy, Pandas, SciPy).
• Machine learning frameworks (PyTorch, TensorFlow, scikit-learn).
• Model development, validation, and evaluation methods.
• Data visualization and exploratory analysis.
• Experience working with noisy and incomplete experimental datasets.

Preferred Skills

• Cheminformatics or molecular modeling tools (RDKit, OpenEye, etc.).
• Multi-omics data analysis.
• Cloud computing environments.
• MLOps or scalable model deployment.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Base Pay Salary Range

$251,000 - $295,000 USD

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [e-mail].