Computational Clinical Scientist II, Clinical Bioinformatics

Revolution Medicines; San Francisco (CA); On-site; USD 132,000 - 166,000; Full time

Job summary

Revolution Medicines is seeking a computational clinical scientist to analyze and interpret molecular and clinical data within Translational Medicine. You will integrate data from ctDNA, RNA sequencing, and other assays to identify biomarkers for candidate oncology drugs.

The role collaborates with biomarker scientists and cross-functional teams to support trial design, protocol development, and regulatory documents. A strong background in bioinformatics and cancer genomics is essential.

Qualifications

• MS/PhD in bioinformatics, biology, data science or related field.
• 2+ years of pharma/biotech experience in bioinformatics focused on oncology.
• Proficiency in R and/or Python.
• Experience with survival analysis and causal inference.
• Experience with cancer genomics data types (RNA, WES, ctDNA) and tools.

Responsibilities

• Integrate multiple data sources including ctDNA, enrollment data, molecular profiling to identify biomarkers.
• Collaborate with internal groups, CROs and collaborators to deliver biomarker data and analysis.
• Support biomarker aspects of trial design, including study protocols and regulatory documents.
• Analyze biomarker readouts with summary statistics and visualization across molecular subgroups.
• Design and interpret experiments with preclinical bioinformaticians to validate biomarkers and mechanisms.

Skills

Biomarker analysis

R/Python

Clinical data analysis

Survival analysis

Causal inference

Oncology domain knowledge

Data visualization

Team collaboration

Education

MS/PhD in bioinformatics, biology, data science or related

Tools

GATK

Salmon

OncoKB

VEP

Job description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

In this role, you will work within our Translational Medicine group analyzing and interpreting molecular and clinical data. Analysis will focus on using genomic, protein and other targeted assays to identify and validate predictive biomarkers. The computational clinical scientist will work on various projects in different phases of drug development and contribute to the cross‑functional team which includes other bioinformaticians, program leads, medical monitors, biostatisticians other pre‑clinical scientists.

• Integrate multiple data sources including circulating tumor DNA, patient enrollment data, molecular profiling (RNA/DNA sequencing outputs), multiplex immunohistochemistry to identify and validate new biomarkers for candidate drugs.
• Work with internal groups, contract research organizations and collaborators to deliver validated biomarker data and analysis.
• Support the development of biomarker related aspects of the trial design where bioinformatic analysis is required, including study protocols, lab manuals, clinical study reports, and other regulatory documents.
• Work with biomarker scientists to support analysis of biomarker readouts (summary statistics, and visualization of efficacy in molecular subgroups).
• Collaborate with preclinical bioinformaticians to design, analyze and interpret experiments to validate biomarkers, understand compound mechanism of action, and identify biomarkers for patient selection and target engagement.

Required Skills, Experience and Education:

• M.S. or Ph.D. in bioinformatics, biology, data science or a related field with emphasis on biological data analysis.
• 2+ years of pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology, or related field.
• Proficiency and experience programming using R and/or Python.
• Proficiency in statistical models and analysis of clinical data. Some ML experience a strong plus.
• Proficiency in visualizations and faceting of molecular data necessary (oncoplots, heatmaps, PCA, etc.).
• Experience with efficacy, baseline demographic, and other outcome data generated in a clinical trial.
• Experience with statistical methods i.e. survival analysis, and causal inference.
• Expertise in bioinformatic analysis of cancer signaling pathways and driver mutations.
• Experience in tools to analyze cancer genomics data types (RNA, WES, ctDNA, etc) and common tool outputs (GATK, Salmon, OncoKB, VEP, etc.) preferred.

Preferred Skills:

• Development with professional software development systems and methods (e.g. IDE’s, ticketing systems, version control systems).
• Familiarity with large public/private genomic data sets (GDC, TCGA, etc.).
• Familiarity with clusters, containers, and cloud computing infrastructure for data processing, analysis, and storage.
• Experience in tools to analyze cancer genomics datasets (GATK, Salmon, OncoKB, VEP, etc.).

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [e-mail].

Base Pay Salary Range

$132,000 - $166,000 USD