Senior Machine Learning Scientist I, Drug Discovery Analytics

Revolution Medicines; San Francisco (CA); On-site; USD 229,000 - 269,000; Full time

Benefits offered by this job

Equity awards

Learning and development opportunities

Robust benefits package

Job summary

Revolution Medicines is seeking a Senior Machine Learning Scientist in San Francisco to enhance drug discovery efforts through machine learning and advanced analytics. You will develop predictive models to transform complex datasets into actionable insights.

This full-time position requires a PhD and 6–10 years of experience in machine learning or data science. Strong collaboration with experimental scientists is crucial to solve complex scientific problems.

The competitive salary for this role ranges from $229,000 to $269,000 USD annually.

Qualifications

• 6–10 years of experience applying machine learning to scientific datasets.
• Experience with noisy and incomplete datasets.
• Familiarity with cheminformatics or molecular modeling tools.

Responsibilities

• Develop predictive models for drug discovery.
• Work with data engineers to integrate models into discovery pipelines.
• Collaborate with research scientists to support compound design.

Skills

Machine learning expertise

Python programming

Data visualization

Advanced analytics

Education

PhD in machine learning or related field

Tools

PyTorch

TensorFlow

NumPy

Pandas

Job description

Overview

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and artificial intelligence. This role will develop predictive models and analytical methods that transform complex biological and chemical datasets into actionable insights that guide research decisions.

The Senior Machine Learning Scientist will work at the interface of data science, chemistry, and biology to support target discovery, compound optimization, and translational research. This position requires both strong machine learning expertise and the ability to collaborate effectively with experimental scientists to solve real-world scientific problems.

The successful candidate will contribute to building a data-driven discovery ecosystem where data, analytics, and experimentation continuously inform and accelerate one another.

Key Responsibilities

• Develop predictive models for drug discovery.
• Independently design and implement machine learning models to predict compound activity, selectivity, and developability.
• Identify and develop predictive frameworks for ADME/Tox, target engagement, and phenotypic screening outcomes.
• Apply advanced modeling approaches including deep learning, graph neural networks, and ensemble methods.
• Evaluate model performance and apply appropriate validation strategies.
• Work with data engineers and ML engineers to integrate models into discovery pipelines.
• Analyze complex scientific data.
• Perform exploratory data analysis on chemical, biological, and phenotypic datasets.
• Integrate heterogeneous datasets including chemical structure and screening data, structural biology and molecular simulation outputs.
• Collaborate with research scientists to support compound design and lead optimization.
• Work with biologists to interpret experimental results and identify new target opportunities.
• Translate scientific questions into computational modeling strategies.

Qualifications

• PhD in machine learning, computational biology, computational chemistry, computer science, statistics, or a related quantitative field.
• 6–10 years of experience applying machine learning or advanced analytics to scientific datasets.
• Python and scientific computing libraries (NumPy, Pandas, SciPy).
• Machine learning frameworks (PyTorch, TensorFlow, scikit-learn).
• Model development, validation, and evaluation methods.
• Data visualization and exploratory analysis.
• Experience working with noisy and incomplete experimental datasets.

Preferred Skills

• Cheminformatics or molecular modeling tools (RDKit, OpenEye, etc.).
• Multi-omics data analysis.
• Cloud computing environments.
• MLOps or scalable model deployment.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [e-mail].

Base Pay Salary Range

$229,000 - $269,000 USD

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