Senior LVV Downstream Engineer | GMP Scale-Up

BioSpace; New Jersey; On-site; USD 146,000 - 192,000; Full time

Benefits offered by this job

Medical, dental, and vision insurance

401(k) with company match

Paid parental leave

Eight weeks PTO and holidays

Job summary

Legend Biotech in Somerset, NJ is seeking a Senior Engineer or Principal Engineer for Lentivirus Downstream Process Development to design, optimize, and scale purification of LVV for GMP manufacturing. You will develop mechanistic models, apply ML, and drive technology transfer from bench to clinic in a collaborative, cross-functional environment.

The role emphasizes modeling, chromatography, TFF, and process control with advisory opportunities, reporting to the Technical Development team in a

Qualifications

• Advanced degree in Chemical/Biomedical Engineering or related field.
• 6+ years (PhD) or 8+ years (MS) in biotech/process development or manufacturing.
• Strong knowledge of bioprocess modeling/simulation and downstream processing.
• Experience with Python and/or MATLAB preferred.
• Strong purification, chromatography, and TFF expertise.
• Understanding GMP and CMC strategies for clinical products.
• Experience with lentiviral vector technologies preferred.

Responsibilities

• Design, optimize, and scale LVV downstream purification processes.
• Build mechanistic and hybrid models to influence LVV downstream development.
• Perform data analytics using ML for process insights.
• Lead tech transfer to GMP manufacturing and support clinical runs.
• Implement APC strategies to optimize performance.
• Collaborate with cross-functional teams to drive project acceleration.
• Prepare technical documents for regulatory submissions.

Skills

Python

MATLAB

Downstream processing

GMP

Communication

Education

PhD in Chemical/Biomedical Engineering or related

MS in Chemical/Bioprocess Engineering

Tools

Modeling software

Job description

Legend Biotech in Somerset, NJ is seeking a Senior Engineer or Principal Engineer for Lentivirus Downstream Process Development to design, optimize, and scale purification of LVV for GMP manufacturing. You will develop mechanistic models, apply ML, and drive technology transfer from bench to clinic in a collaborative, cross-functional environment.

The role emphasizes modeling, chromatography, TFF, and process control with advisory opportunities, reporting to the Technical Development team in a