Senior Lung Immunology Scientist — Target Discovery & MOA

F. Hoffmann-La Roche AG; South San Francisco (CA); Hybrid; USD 103,000 - 192,000; Full time

Benefits offered by this job

Discretionary annual bonus

Job summary

Genentech, a member of the Roche group, is seeking a Scientist in Immunology with deep expertise in lung biology to uncover novel targets for respiratory diseases. You will lead projects exploring cellular mechanisms of lung injury, inflammation, and repair, and help advance programs into early clinical development.

The role requires a PhD with publications, hands-on molecular biology and organoid/ALI or organ-on-a-chip experience, and strong collaboration across departments.

Qualifications

• PhD in immunology, stem cell biology, molecular biology, biochemistry, or related field with strong publications.
• Deep understanding of lung biology, especially chronic respiratory diseases, tissue remodeling or host-microbe interactions.
• Hands-on expertise in molecular biology including transfections, gene expression profiling, genome editing, and RNA delivery.
• Experience with primary cell isolation from human or mouse tissues and multi-dimensional flow cytometry.
• Independent design/execution of complex experiments leading to first-author publications.

Responsibilities

• Lead research projects on cellular/molecular mechanisms of lung injury and repair.
• Advance research programs into early clinical development with robust proof-of-concept data.
• Utilize in vitro/in vivo models to evaluate novel molecules and delivery systems.
• Investigate MOA of therapies and contribute to target discovery.
• Collaborate across immunology, genetics, biomarkers, and early clinical development and present findings.

Skills

Lung biology expertise

Immunology experience

Flow cytometry

Organoid culture

Molecular biology techniques

RNA delivery technologies

In vitro/in vivo models

Education

PhD in immunology or related field

Tools

Air–liquid interface (ALI) 3D cultures

Organs-on-a-chip

Job description

Genentech, a member of the Roche group, is seeking a Scientist in Immunology with deep expertise in lung biology to uncover novel targets for respiratory diseases. You will lead projects exploring cellular mechanisms of lung injury, inflammation, and repair, and help advance programs into early clinical development.

The role requires a PhD with publications, hands-on molecular biology and organoid/ALI or organ-on-a-chip experience, and strong collaboration across departments.