Senior Isotopic Chemist, Radiolabeling & Metabolites

BioSpace; Indianapolis (IN); On-site; USD 153,000 - 246,000; Full time

Benefits offered by this job

401k program

Pension

Vacation benefits

Medical, dental, vision

Flexible benefits

Life insurance

Time off

Well-being program

Job summary

Lilly in Indianapolis is seeking a highly motivated isotopic chemist to lead synthesis of radiolabeled compounds and oversee outsourced labs. You will design isotopic labels, collaborate with ADME, clinical pharmacology, and CMC teams, and contribute to regulatory submissions.

Candidates should have MS in Chemistry with radiochemistry and stable isotope experience; PhD preferred. The role offers full-time employment with comprehensive benefits and potential bonuses.

Qualifications

• MS in Chemistry with 8 years of experience in isotopic chemistry.
• Experience in radiochemistry and stable isotope chemistry.

Responsibilities

• Provide scientific oversight of synthetic projects and outsourced activities related to the preparation of isotopically labeled compounds and metabolites to ensure on-time delivery and high quality of compounds to support Lilly portfolio.
• Collaborate with Lilly’s chemists and design synthetic routes for introduction of radiolabels and stable isotope labels in the molecules of drug candidates.
• Work closely with ADME scientists on selecting metabolically stable position for radiolabeling.
• Interact with bioanalytical teams to outline synthetic target for compounds labeled with stable isotopes.
• Develop new synthetic methods for the preparation of putative metabolites.
• Partner with external CRO resources to implement design ideas of Isotopic synthesis.
• Work within clinical pharmacology and CMC teams to ensure delivery of radiolabeled compounds for human clinical trials.
• Prepare appropriate sections of IND for regulatory submission.
• Present at internal or external forums

Skills

Isotopic Chemistry

Radiochemistry

Stable isotope chemistry

Cross-functional collaboration

Communication skills

Education

MS in Chemistry

PhD in Organic Chemistry

Job description

Lilly in Indianapolis is seeking a highly motivated isotopic chemist to lead synthesis of radiolabeled compounds and oversee outsourced labs. You will design isotopic labels, collaborate with ADME, clinical pharmacology, and CMC teams, and contribute to regulatory submissions.

Candidates should have MS in Chemistry with radiochemistry and stable isotope experience; PhD preferred. The role offers full-time employment with comprehensive benefits and potential bonuses.