Lead Radiochemist - Isotopically Labeled Synthesis

American Radiolabeled Chemicals, Inc.; St. Louis (MO); On-site; USD 90,000 - 130,000; Full time

Job summary

American Radiolabeled Chemicals, Inc. seeks a skilled radiochemistry chemist to design and execute multi-step syntheses of Carbon-14 and Tritium labeled compounds.

You will develop routes for custom projects, purify intermediates and products, and verify identity with HPLC, MS, NMR, and IR. Responsibilities include troubleshooting challenging purification steps, maintaining detailed notebooks, and producing technical summaries.

Qualifications

• Significant hands-on experience in multi-step organic synthesis, preferably involving Carbon-14 and Tritium labeled compounds.
• Independently execute multi-step synthetic chemistry.
• Strong purification and isolation skills, including HPLC, flash chromatography, SPE, crystallization, and LLE.
• Experience purifying intermediates and final compounds with analytical confirmation.
• Excellent lab documentation and organizational skills.
• Strong troubleshooting and problem-solving abilities.
• Ability to work independently and collaboratively.

Responsibilities

• Design and execute multi-step organic syntheses of Carbon-14 and Tritium labeled compounds.
• Develop and optimize synthetic routes for custom client projects.
• Purify and isolate intermediates and final radiolabeled compounds using HPLC, flash chromatography, SPE, crystallization, and LLE.
• Identify and characterize synthesized compounds using HPLC, MS, NMR, and IR; assess quality.
• Troubleshoot difficult synthetic and purification challenges.
• Maintain laboratory notebooks, experimental records, and project documentation.
• Prepare technical summaries and supporting documentation.
• Ensure safety when handling radioactive materials and collaborate with team.

Skills

Multi-step synthesis

Radiochemistry

Project management

Troubleshooting

Analytical skills

Documentation

Team collaboration

Isotopic labeling

Education

B.S./M.S./Ph.D. in Chemistry

Tools

HPLC

Flash chromatography

Solid-phase extraction

Crystallization

Liquid-liquid extraction

MS

NMR

IR

Job description

American Radiolabeled Chemicals, Inc. seeks a skilled radiochemistry chemist to design and execute multi-step syntheses of Carbon-14 and Tritium labeled compounds.

You will develop routes for custom projects, purify intermediates and products, and verify identity with HPLC, MS, NMR, and IR. Responsibilities include troubleshooting challenging purification steps, maintaining detailed notebooks, and producing technical summaries.