Senior Information Security Engineer: AI/SSDLC Leader

Mayo Career Site US; Rochester (MN); On-site; USD 120,000 - 180,000; Full time

Job summary

Mayo Clinic in Rochester, MN seeks a Senior Information Security Engineer to lead complex security initiatives. This senior-level technical role provides advanced expertise across information security domains, operates with autonomy, and serves as a technical authority designing, implementing, and optimizing security solutions to address enterprise risk.

The scope includes SSDLC initiatives to enable security in software development and delivery pipelines, and research into agentic and

Qualifications

• Senior-level security engineering experience with autonomy and technical authority.
• Experience implementing SSDLC and secure software development practices.
• Ability to translate security requirements into scalable solutions.
• Collaborative mindset across Information Security and IT teams.

Responsibilities

• Lead complex security engineering initiatives across multiple domains.
• Design, implement and optimize security solutions to address enterprise risk.
• Collaborate with development teams to enable security in pipelines.
• Research emerging agentic and AI-assisted development risks and controls.
• Evaluate security technologies and capabilities for AI-enabled software

Skills

Security engineering

SSDLC

AI/agentic security

Lead cross-functional initiatives

Education

Bachelor’s degree in Computer Science or related field

Job description

Mayo Clinic in Rochester, MN seeks a Senior Information Security Engineer to lead complex security initiatives. This senior-level technical role provides advanced expertise across information security domains, operates with autonomy, and serves as a technical authority designing, implementing, and optimizing security solutions to address enterprise risk.

The scope includes SSDLC initiatives to enable security in software development and delivery pipelines, and research into agentic and