Senior Facilities Engineering Manager

Immatics; Houston (TX); On-site; USD 150,000 - 190,000; Full time

Benefits offered by this job

Health insurance

Vacation & holidays

Life insurance

Disability coverage

401(k) with company match

Job summary

Immatics is seeking a Senior Facilities Engineering Manager to lead GMP manufacturing equipment validation, utilities and facility assets across production and lab operations. You will drive IQ/OQ/PQ strategies, ensure reliability, and partner with Quality on deviations and CAPAs.

Location: Stafford, TX; Monday–Friday with on-call as needed. Qualifications include a Bachelors in a related engineering field, 7+ years in pharma/biotech with 5+ years leading teams, and strong GMP knowledge.

Qualifications

• 7+ years in pharma/biotech engineering within a GxP environment.
• 5+ years of direct people leadership experience.
• Experience validating GMP manufacturing equipment and utilities.

Responsibilities

• Lead validation and qualification of GMP equipment, utilities, HVAC, cleanrooms, and gases.
• Oversee IQ/OQ/PQ strategies and validation lifecycle management.
• Develop preventive/predictive maintenance and asset lifecycle planning.
• Support tech transfer from late-stage clinical to commercial operations.
• Collaborate with Quality to manage deviations, CAPAs, and change controls.
• Mentor and coach engineering teams and manage budgets/KPIs.
• Perform engineering duties when required.

Skills

FDA & cGMP know-how

IQ/OQ/PQ with CSV

Cleanrooms & critical utilities

Biologics/cell therapy manufacturing

CMMS/BMS/EMS familiarity

PMP certification advantageous

21 CFR 11/210/211, EU Annex 1, USP

Deviations & CAPA investigations

Education

Bachelor’s degree in Mechanical, Electrical, Chemical Engineering or related field

Tools

None

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

We are seeking a Senior Facilities Engineering Manager to lead the Facilities Engineering team responsible for ensuring GMP manufacturing equipment, utilities, and facility assets are qualified and validated, reliable and available for production and lab operations, ready for Phase III manufacturing and commercial launch, and continuously improved using reliability engineering principles. This role bridges Facilities Engineering, CMC Manufacturing, CSV, and Quality (OQA, QAV).

Schedule: Monday to Friday; 8:00 am – 5:00 pm; on-call support as needed

Reports to: Director, Facilities, Engineering, & Asset Lifecycle

Location: 13203 Murphy Road Suite 100 Stafford, TX 77477

Basic Qualifications

• Bachelors degree in Mechanical, Electrical, Chemical Engineering, or related field
• 7+ years in pharmaceutical or biotech engineering within a GxP regulated manufacturing or laboratory environment, with 5+ of those years directly leading teams

Preferred Qualifications:

• Strong knowledge of FDA and cGMP requirements
• Deep experience with IQ/OQ/PQ with exposure to CSV interfaces
• Expertise in cleanrooms and critical utilities
• Experience supporting commercial biologics or cell therapy manufacturing
• Familiarity with CMMS, BMS/EMS, digital maintenance systems
• PMP or similar certification is advantageous
• Demonstrated understanding of 21 CFR Part 11, 21 CFR Part 210, 21 CFR Part 211, EU Annex 1, and USP
• Experience in writing and reviewing Deviations and CAPAs, investigations resulting from OOS/OOT, environmental excursions, lab investigations leading to Change Controls for QMS.

In This Role You Will

• Lead validation and qualification of GMP manufacturing equipment, process utilities, HVAC systems, cleanrooms, compressed gases, etc.
• Oversee IQ, OQ, PQ, Requalification strategy, and Validation lifecycle management.
• Develop and manage preventive maintenance, predictive maintenance, reliability-centered maintenance, asset criticality analysis and equipment lifecycle planning to maximize equipment uptime, reduce unplanned downtime and improve overall equipment effectiveness.
• Support transition from late-stage clinical manufacturing to commercial operations
• Partner with Quality to manage deviations, lead equipment investigations, execute CAPAs, and support change control.
• Lead, mentor, and coach equipment validation engineers and reliability engineers.
• Manage engineering budgets and KPIs.
• Perform engineering duties when necessary

What do we offer?

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics

Comprehensive Benefits:

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insuranceup to at 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short- and long-Term disability coverage
• 401(k) with immediate eligibilityand company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
• Partially paid parental leavefor eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard torace, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexualorientation, gender identity or expression, national origin, ancestry, age, marital status, disability, geneticinformation, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants withsincerely heldreligious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us [e-mail].

Work Authorization

Applicants mustbe authorized towork in the United States without the need for current or future sponsorship.

Pre-Employment Requirements

Employment is contingent upon successful completion of a background check, referencechecksand pre-employment drug screening, wherepermittedby applicable law. For certain roles,additionalscreenings such as a credit check or motor vehicle record review may berequired, where job-related and consistent with business necessity.